| http://purl.uniprot.org/citations/31758917 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31758917 | http://www.w3.org/2000/01/rdf-schema#comment | "Atorvastatin is a commonly prescribed statin drug for the control of lipid synthesis and recent studies have shown the cardiac protection potential of atorvastatin. Cardiac fibrosis is a critical process that impairs heart function. In the current study, the anti-fibrosis potential of atorvastatin was assessed and the mechanism associated with the treatment was explored. Fibrotic symptoms were induced using transverse aortic constriction (TAC) method in vivo and using TGF-β1 in vitro. The effect of atorvastatin on the development of cardiac fibrosis was firstly measured. Moreover, the influence of miR-143-3p induction on the anti-fibrosis function of atorvastatin was determined. TAC administration induced cardiac fibrosis and heart weight increase, which was associated with the induced expressions of TGF-β1, miR-143-3p, p-Smad2, and collagens. Atorvastatin restored the levels of TGF-β1, miR-143-3p, p-Smad2, and collagens. The administration of TGF-β1 induced the expressions of miR-143-3p, p-Smad2, and collagens in cardiac fibroblasts (CFs) and the effect was inhibited by atorvastatin. However, the function of atorvastatin was blocked by miR-143-3p mimics. The current study demonstrated that the suppression of miR-143-3p contributed to the anti-fibrosis effect of atorvastatin on myocardial tissues, which subsequently inhibited Smad2-mediated production of collagens."xsd:string |
| http://purl.uniprot.org/citations/31758917 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.yexmp.2019.104346"xsd:string |
| http://purl.uniprot.org/citations/31758917 | http://purl.uniprot.org/core/author | "Shi K."xsd:string |
| http://purl.uniprot.org/citations/31758917 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
| http://purl.uniprot.org/citations/31758917 | http://purl.uniprot.org/core/author | "Yu M."xsd:string |
| http://purl.uniprot.org/citations/31758917 | http://purl.uniprot.org/core/author | "Yu B."xsd:string |
| http://purl.uniprot.org/citations/31758917 | http://purl.uniprot.org/core/author | "Xie D."xsd:string |
| http://purl.uniprot.org/citations/31758917 | http://purl.uniprot.org/core/author | "Nie W."xsd:string |
| http://purl.uniprot.org/citations/31758917 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/31758917 | http://purl.uniprot.org/core/name | "Exp Mol Pathol"xsd:string |
| http://purl.uniprot.org/citations/31758917 | http://purl.uniprot.org/core/pages | "104346"xsd:string |
| http://purl.uniprot.org/citations/31758917 | http://purl.uniprot.org/core/title | "Suppression of miR-143-3p contributes to the anti-fibrosis effect of atorvastatin on myocardial tissues via the modulation of Smad2 activity."xsd:string |
| http://purl.uniprot.org/citations/31758917 | http://purl.uniprot.org/core/volume | "112"xsd:string |
| http://purl.uniprot.org/citations/31758917 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31758917 |
| http://purl.uniprot.org/citations/31758917 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31758917 |
| http://purl.uniprot.org/uniprot/#_A0A0G2K0P2-mappedCitation-31758917 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31758917 |
| http://purl.uniprot.org/uniprot/#_A0A8I5ZQC4-mappedCitation-31758917 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31758917 |
| http://purl.uniprot.org/uniprot/#_A6KMS7-mappedCitation-31758917 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31758917 |
| http://purl.uniprot.org/uniprot/#_A6KMS9-mappedCitation-31758917 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31758917 |
| http://purl.uniprot.org/uniprot/#_O70436-mappedCitation-31758917 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31758917 |
| http://purl.uniprot.org/uniprot/A0A0G2K0P2 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/31758917 |
| http://purl.uniprot.org/uniprot/A6KMS9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/31758917 |
| http://purl.uniprot.org/uniprot/A0A8I5ZQC4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/31758917 |
| http://purl.uniprot.org/uniprot/A6KMS7 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/31758917 |