| http://purl.uniprot.org/citations/31761329 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31761329 | http://www.w3.org/2000/01/rdf-schema#comment | "Long non-coding RNAs (lncRNAs) have been unveiled to play crucial parts in tumorigenesis and chemo-resistance of multiple cancers. Herein, we explored the role of NCK1-AS1 in ovarian cancer (OC). As indicated by TCGA, NCK1-AS1 was markedly upregulated in OC tissues. Besides, we found a dramatic upregulation of NCK1-AS1 in OC cell lines relative to the normal IOSE cells. Interestingly, silencing NCK1-AS1 confined cell proliferation, induced apoptosis and suppressed migration and invasion as well as enhanced DDP sensitivity in OC cells. As for mechanistic investigation, starBase (http://starbase.sysu.edu.cn/) suggested that NCK1-AS1 expression in OC tissues was significantly positively correlated with its adjacent gene, NCK adaptor protein 1 (NCK1). Furtherly, we demonstrated that the cytoplasmic NCK1-AS1 competed with NCK1 mRNA for miR-137 binding to boost NCK1 mRNA expression. Importantly, miR-137 inhibition could only offset the suppression of NCK1-AS1 depletion on NCK1 mRNA level but not the protein level. Moreover, NCK1-AS1 stabilized NCK1 protein by hindering c-Cbl-induced degradation via directly interacting with c-Cbl. Furthermore, NCK1 upregulation reversed the influences of NCK1-AS1 inhibition on the biological behaviors and DDP resistance of OC cells. This study disclosed a NCK1-AS1/NCK1 axis in regulating OC progression and chemo-resistance, opening a new path for treatment and chemo-resistance overcoming in OC."xsd:string |
| http://purl.uniprot.org/citations/31761329 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2019.11.014"xsd:string |
| http://purl.uniprot.org/citations/31761329 | http://purl.uniprot.org/core/author | "Chang H."xsd:string |
| http://purl.uniprot.org/citations/31761329 | http://purl.uniprot.org/core/author | "Li B."xsd:string |
| http://purl.uniprot.org/citations/31761329 | http://purl.uniprot.org/core/author | "Zhang X."xsd:string |
| http://purl.uniprot.org/citations/31761329 | http://purl.uniprot.org/core/author | "Meng X."xsd:string |
| http://purl.uniprot.org/citations/31761329 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/31761329 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/31761329 | http://purl.uniprot.org/core/pages | "292-299"xsd:string |
| http://purl.uniprot.org/citations/31761329 | http://purl.uniprot.org/core/title | "NCK1-AS1 promotes NCK1 expression to facilitate tumorigenesis and chemo-resistance in ovarian cancer."xsd:string |
| http://purl.uniprot.org/citations/31761329 | http://purl.uniprot.org/core/volume | "522"xsd:string |
| http://purl.uniprot.org/citations/31761329 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31761329 |
| http://purl.uniprot.org/citations/31761329 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31761329 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z4Y3-mappedCitation-31761329 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31761329 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z4D7-mappedCitation-31761329 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31761329 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z4E4-mappedCitation-31761329 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31761329 |
| http://purl.uniprot.org/uniprot/#_B2R6S4-mappedCitation-31761329 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31761329 |
| http://purl.uniprot.org/uniprot/#_P16333-mappedCitation-31761329 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31761329 |
| http://purl.uniprot.org/uniprot/B2R6S4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/31761329 |
| http://purl.uniprot.org/uniprot/A0A0S2Z4D7 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/31761329 |
| http://purl.uniprot.org/uniprot/A0A0S2Z4E4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/31761329 |
| http://purl.uniprot.org/uniprot/A0A0S2Z4Y3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/31761329 |
| http://purl.uniprot.org/uniprot/P16333 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/31761329 |