| http://purl.uniprot.org/citations/31767615 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31767615 | http://www.w3.org/2000/01/rdf-schema#comment | "The PI3K pathway is integral for the germinal center (GC) response. However, the contribution of protein kinase B (AKT) as a PI3K effector in GC B cells remains unknown. Here, we show that mice lacking the AKT1 and AKT2 isoforms in B cells failed to form GCs, which undermined affinity maturation and antibody production in response to immunization. Upon B-cell receptor stimulation, AKT1/2-deficient B cells showed poor survival, reduced proliferation, and impaired mitochondrial and metabolic fitness, which collectively halted GC development. By comparison, Foxo1 T24A mutant, which cannot be inactivated by AKT1/2 phosphorylation and is sequestered in the nucleus, significantly enhanced antibody class switch recombination via induction of activation-induced cytidine deaminase (AID) expression. By contrast, repression of FOXO1 activity by AKT1/2 promoted IRF4-driven plasma cell differentiation. Last, we show that T-cell help via CD40, but not enforced expression of Bcl2, rescued the defective GC response in AKT1/2-deficient animals by restoring proliferative expansion and energy production. Overall, our study provides mechanistic insights into the key role of AKT and downstream pathways on B cell fate decisions during the GC response."xsd:string |
| http://purl.uniprot.org/citations/31767615 | http://purl.org/dc/terms/identifier | "doi:10.26508/lsa.201900506"xsd:string |
| http://purl.uniprot.org/citations/31767615 | http://purl.uniprot.org/core/author | "Zhu Z."xsd:string |
| http://purl.uniprot.org/citations/31767615 | http://purl.uniprot.org/core/author | "Shukla A."xsd:string |
| http://purl.uniprot.org/citations/31767615 | http://purl.uniprot.org/core/author | "Rickert R.C."xsd:string |
| http://purl.uniprot.org/citations/31767615 | http://purl.uniprot.org/core/author | "Apgar J.R."xsd:string |
| http://purl.uniprot.org/citations/31767615 | http://purl.uniprot.org/core/author | "Ramezani-Rad P."xsd:string |
| http://purl.uniprot.org/citations/31767615 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31767615 | http://purl.uniprot.org/core/name | "Life Sci Alliance"xsd:string |
| http://purl.uniprot.org/citations/31767615 | http://purl.uniprot.org/core/pages | "e201900506"xsd:string |
| http://purl.uniprot.org/citations/31767615 | http://purl.uniprot.org/core/title | "The AKT isoforms 1 and 2 drive B cell fate decisions during the germinal center response."xsd:string |
| http://purl.uniprot.org/citations/31767615 | http://purl.uniprot.org/core/volume | "2"xsd:string |
| http://purl.uniprot.org/citations/31767615 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31767615 |
| http://purl.uniprot.org/citations/31767615 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31767615 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YWR2-mappedCitation-31767615 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31767615 |
| http://purl.uniprot.org/uniprot/#_D3Z783-mappedCitation-31767615 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31767615 |
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| http://purl.uniprot.org/uniprot/#_D3Z0M3-mappedCitation-31767615 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31767615 |
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| http://purl.uniprot.org/uniprot/#_D3YXM7-mappedCitation-31767615 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31767615 |
| http://purl.uniprot.org/uniprot/#_D3YXX3-mappedCitation-31767615 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31767615 |
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| http://purl.uniprot.org/uniprot/#_A4FUQ9-mappedCitation-31767615 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31767615 |