| http://purl.uniprot.org/citations/31767934 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31767934 | http://www.w3.org/2000/01/rdf-schema#comment | "Lung cancer is one of the cancers with highest morbidity and mortality rates and the metastasis of lung cancer is a leading cause of death. Mechanisms of lung cancer metastasis are yet to be fully understood. Herein, we demonstrate that mice deficient for REGγ, a proteasome activator, exhibited a significant reduction in tumor size, numbers, and metastatic rate with prolonged survival in a conditional Kras/p53 mutant lung cancer model. REGγ enhanced the TGFβ-Smad signaling pathway by ubiquitin-ATP-independent degradation of Smad7, an inhibitor of the TGFβ pathway. Activated TGFβ signaling in REGγ-positive lung cancer cells led to diminished expression of E-cadherin, a biomarker of epithelial-mesenchymal transitions (EMT), and elevated mesenchymal markers compared with REGγ-deficient lung cancer cells. REGγ overexpression was found in lung cancer patients with metastasis, correlating with the reduction of E-Cadherin/Smad7 and a poor prognosis. Overall, our study indicates that REGγ promotes lung cancer metastasis by activating TGF-β signaling via degradation of Smad7. Thus, REGγ may serve as a novel therapeutic target for lung cancers with poor prognosis."xsd:string |
| http://purl.uniprot.org/citations/31767934 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41418-019-0459-6"xsd:string |
| http://purl.uniprot.org/citations/31767934 | http://purl.uniprot.org/core/author | "Chen G."xsd:string |
| http://purl.uniprot.org/citations/31767934 | http://purl.uniprot.org/core/author | "Liu Q."xsd:string |
| http://purl.uniprot.org/citations/31767934 | http://purl.uniprot.org/core/author | "Huang Q."xsd:string |
| http://purl.uniprot.org/citations/31767934 | http://purl.uniprot.org/core/author | "Li L."xsd:string |
| http://purl.uniprot.org/citations/31767934 | http://purl.uniprot.org/core/author | "Li K."xsd:string |
| http://purl.uniprot.org/citations/31767934 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/31767934 | http://purl.uniprot.org/core/author | "Huang T."xsd:string |
| http://purl.uniprot.org/citations/31767934 | http://purl.uniprot.org/core/author | "Pan L."xsd:string |
| http://purl.uniprot.org/citations/31767934 | http://purl.uniprot.org/core/author | "Tong L."xsd:string |
| http://purl.uniprot.org/citations/31767934 | http://purl.uniprot.org/core/author | "Yang X."xsd:string |
| http://purl.uniprot.org/citations/31767934 | http://purl.uniprot.org/core/author | "Zhang P."xsd:string |
| http://purl.uniprot.org/citations/31767934 | http://purl.uniprot.org/core/author | "Shen S."xsd:string |
| http://purl.uniprot.org/citations/31767934 | http://purl.uniprot.org/core/author | "Xie S."xsd:string |
| http://purl.uniprot.org/citations/31767934 | http://purl.uniprot.org/core/author | "Wang T."xsd:string |
| http://purl.uniprot.org/citations/31767934 | http://purl.uniprot.org/core/author | "Fu J."xsd:string |
| http://purl.uniprot.org/citations/31767934 | http://purl.uniprot.org/core/author | "Moses R.E."xsd:string |
| http://purl.uniprot.org/citations/31767934 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/31767934 | http://purl.uniprot.org/core/name | "Cell Death Differ"xsd:string |
| http://purl.uniprot.org/citations/31767934 | http://purl.uniprot.org/core/pages | "1795-1806"xsd:string |
| http://purl.uniprot.org/citations/31767934 | http://purl.uniprot.org/core/title | "Proteasome-dependent degradation of Smad7 is critical for lung cancer metastasis."xsd:string |
| http://purl.uniprot.org/citations/31767934 | http://purl.uniprot.org/core/volume | "27"xsd:string |
| http://purl.uniprot.org/citations/31767934 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31767934 |