| http://purl.uniprot.org/citations/31768046 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31768046 | http://www.w3.org/2000/01/rdf-schema#comment | "Tendon injuries cause prolonged disability and never recover completely. Current mechanistic understanding of tendon regeneration is limited. Here, we use single-cell transcriptomics to identify a tubulin polymerization-promoting protein family member 3-expressing (Tppp3+) cell population as potential tendon stem cells. Through inducible lineage tracing, we demonstrate that these cells can generate new tenocytes and self-renew upon injury. A fraction of Tppp3+ cells expresses platelet-derived growth factor receptor alpha (Pdfgra). Ectopic platelet-derived growth factor-AA (PDGF-AA) protein induces new tenocyte production while inactivation of Pdgfra in Tppp3+ cells blocks tendon regeneration. These results support Tppp3+Pdgfra+ cells as tendon stem cells. Unexpectedly, Tppp3-Pdgfra+ fibro-adipogenic progenitors coexist in the tendon stem cell niche and give rise to fibrotic cells, revealing a clandestine origin of fibrotic scars in healing tendons. Our results explain why fibrosis occurs in injured tendons and present clinical challenges to enhance tendon regeneration without a concurrent increase in fibrosis by PDGF application."xsd:string |
| http://purl.uniprot.org/citations/31768046 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41556-019-0417-z"xsd:string |
| http://purl.uniprot.org/citations/31768046 | http://purl.uniprot.org/core/author | "Harvey T."xsd:string |
| http://purl.uniprot.org/citations/31768046 | http://purl.uniprot.org/core/author | "Fan C.M."xsd:string |
| http://purl.uniprot.org/citations/31768046 | http://purl.uniprot.org/core/author | "Flamenco S."xsd:string |
| http://purl.uniprot.org/citations/31768046 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31768046 | http://purl.uniprot.org/core/name | "Nat Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/31768046 | http://purl.uniprot.org/core/pages | "1490-1503"xsd:string |
| http://purl.uniprot.org/citations/31768046 | http://purl.uniprot.org/core/title | "A Tppp3+Pdgfra+ tendon stem cell population contributes to regeneration and reveals a shared role for PDGF signalling in regeneration and fibrosis."xsd:string |
| http://purl.uniprot.org/citations/31768046 | http://purl.uniprot.org/core/volume | "21"xsd:string |
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| http://purl.uniprot.org/uniprot/#_A0A3B2WB94-mappedCitation-31768046 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31768046 |