| http://purl.uniprot.org/citations/31775043 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31775043 | http://www.w3.org/2000/01/rdf-schema#comment | "B cell development depends on the coordinated expression and cooperation of several transcription factors. Here we show that the transcription factor ETS-related gene (ERG) is crucial for normal B cell development and that its deletion results in a substantial loss of bone marrow B cell progenitors and peripheral B cells, as well as a skewing of splenic B cell populations. We find that ERG-deficient B lineage cells exhibit an early developmental block at the pre-B cell stage and proliferate less. The cells fail to express the immunoglobulin heavy chain due to inefficient V-to-DJ recombination, and cells that undergo recombination display a strong bias against incorporation of distal V gene segments. Furthermore, antisense transcription at PAX5-activated intergenic repeat (PAIR) elements, located in the distal region of the Igh locus, depends on ERG. These findings show that ERG serves as a critical regulator of B cell development by ensuring efficient and balanced V-to-DJ recombination."xsd:string |
| http://purl.uniprot.org/citations/31775043 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2019.10.098"xsd:string |
| http://purl.uniprot.org/citations/31775043 | http://purl.uniprot.org/core/author | "Mandrup S."xsd:string |
| http://purl.uniprot.org/citations/31775043 | http://purl.uniprot.org/core/author | "Rauch A."xsd:string |
| http://purl.uniprot.org/citations/31775043 | http://purl.uniprot.org/core/author | "Rehn M."xsd:string |
| http://purl.uniprot.org/citations/31775043 | http://purl.uniprot.org/core/author | "Hasemann M.S."xsd:string |
| http://purl.uniprot.org/citations/31775043 | http://purl.uniprot.org/core/author | "Jendholm J."xsd:string |
| http://purl.uniprot.org/citations/31775043 | http://purl.uniprot.org/core/author | "Porse B.T."xsd:string |
| http://purl.uniprot.org/citations/31775043 | http://purl.uniprot.org/core/author | "Rapin N."xsd:string |
| http://purl.uniprot.org/citations/31775043 | http://purl.uniprot.org/core/author | "Martensson I.L."xsd:string |
| http://purl.uniprot.org/citations/31775043 | http://purl.uniprot.org/core/author | "Michaut M."xsd:string |
| http://purl.uniprot.org/citations/31775043 | http://purl.uniprot.org/core/author | "Sondergaard E."xsd:string |
| http://purl.uniprot.org/citations/31775043 | http://purl.uniprot.org/core/author | "Wilhelmson A.S."xsd:string |
| http://purl.uniprot.org/citations/31775043 | http://purl.uniprot.org/core/author | "Bagger F.O."xsd:string |
| http://purl.uniprot.org/citations/31775043 | http://purl.uniprot.org/core/author | "Knudsen K.J."xsd:string |
| http://purl.uniprot.org/citations/31775043 | http://purl.uniprot.org/core/author | "Camponeschi A."xsd:string |
| http://purl.uniprot.org/citations/31775043 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31775043 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/31775043 | http://purl.uniprot.org/core/pages | "2756-2769.e6"xsd:string |
| http://purl.uniprot.org/citations/31775043 | http://purl.uniprot.org/core/title | "ERG Controls B Cell Development by Promoting Igh V-to-DJ Recombination."xsd:string |
| http://purl.uniprot.org/citations/31775043 | http://purl.uniprot.org/core/volume | "29"xsd:string |
| http://purl.uniprot.org/citations/31775043 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31775043 |
| http://purl.uniprot.org/citations/31775043 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31775043 |
| http://purl.uniprot.org/uniprot/#_A0A384DVA0-mappedCitation-31775043 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31775043 |