| http://purl.uniprot.org/citations/31775046 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31775046 | http://www.w3.org/2000/01/rdf-schema#comment | "Germinal centers (GC) are crucial for the formation of long-lived humoral immunity. Many pathogens suppress GC, including Salmonella enterica serovar Typhimurium (STm), but the mechanisms driving suppression remain unknown. We report that neither plasmablasts nor STm-specific B cells are required for GC suppression in mice. Rather, we identify that interleukin-12 (IL-12), but not interferon-γ (IFN-γ), directly suppresses T follicular helper (Tfh) cell differentiation of T cells intrinsically. Administering recombinant IL-12 during nitrophenyl-Chicken Gamma Globulin (NP-CGG) immunization also suppresses Tfh cell differentiation and GC B cells, indicating that IL-12 is sufficient to suppress Tfh cell differentiation independent of STm infection. Recombinant IL-12 induces high levels of T-bet, and T-bet is necessary for Tfh cell suppression. Therefore, IL-12 induced during STm infection in mice contributes to GC suppression via suppression of Tfh cell differentiation. More broadly, these data suggest that IL-12 can tailor the proportions of humoral (Tfh cell) and cellular (T helper type 1 [Th1] cell) immunity to the infection, with implications for IL-12 targeting therapies in autoimmunity and vaccination."xsd:string |
| http://purl.uniprot.org/citations/31775046 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2019.10.069"xsd:string |
| http://purl.uniprot.org/citations/31775046 | http://purl.uniprot.org/core/author | "Shlomchik M.J."xsd:string |
| http://purl.uniprot.org/citations/31775046 | http://purl.uniprot.org/core/author | "Elsner R.A."xsd:string |
| http://purl.uniprot.org/citations/31775046 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31775046 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/31775046 | http://purl.uniprot.org/core/pages | "2796-2809.e5"xsd:string |
| http://purl.uniprot.org/citations/31775046 | http://purl.uniprot.org/core/title | "IL-12 Blocks Tfh Cell Differentiation during Salmonella Infection, thereby Contributing to Germinal Center Suppression."xsd:string |
| http://purl.uniprot.org/citations/31775046 | http://purl.uniprot.org/core/volume | "29"xsd:string |
| http://purl.uniprot.org/citations/31775046 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31775046 |
| http://purl.uniprot.org/citations/31775046 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31775046 |
| http://purl.uniprot.org/uniprot/#_P15261-mappedCitation-31775046 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31775046 |
| http://purl.uniprot.org/uniprot/#_A0A0X1KG58-mappedCitation-31775046 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31775046 |
| http://purl.uniprot.org/uniprot/#_I7CPP0-mappedCitation-31775046 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31775046 |
| http://purl.uniprot.org/uniprot/#_E9PX11-mappedCitation-31775046 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31775046 |
| http://purl.uniprot.org/uniprot/#_D3Z6H5-mappedCitation-31775046 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31775046 |
| http://purl.uniprot.org/uniprot/#_Q540M5-mappedCitation-31775046 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31775046 |
| http://purl.uniprot.org/uniprot/#_Q3U1A5-mappedCitation-31775046 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31775046 |
| http://purl.uniprot.org/uniprot/#_Q60636-mappedCitation-31775046 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31775046 |
| http://purl.uniprot.org/uniprot/#_P25918-mappedCitation-31775046 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31775046 |
| http://purl.uniprot.org/uniprot/#_Q3U8T2-mappedCitation-31775046 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31775046 |
| http://purl.uniprot.org/uniprot/#_Q5PSB0-mappedCitation-31775046 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31775046 |
| http://purl.uniprot.org/uniprot/#_P97378-mappedCitation-31775046 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31775046 |
| http://purl.uniprot.org/uniprot/#_Q3TQG5-mappedCitation-31775046 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31775046 |