| http://purl.uniprot.org/citations/31775048 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31775048 | http://www.w3.org/2000/01/rdf-schema#comment | "Intestinal microfold cells (M cells) in Peyer's patches are a special subset of epithelial cells that initiate mucosal immune responses through uptake of luminal antigens. Although the cytokine receptor activator of nuclear factor-κB ligand (RANKL) expressed on mesenchymal cells triggers differentiation into M cells, other environmental cues remain unknown. Here, we show that the metastasis-promoting protein S100A4 is required for development of mature M cells. S100A4-producing cells are a heterogenous cell population including lysozyme-expressing dendritic cells and group 3 innate lymphoid cells. We found that in the absence of DOCK8, a Cdc42 activator critical for interstitial leukocyte migration, S100A4-producing cells are reduced in the subepithelial dome, resulting in a maturation defect of M cells. While S100A4 promotes differentiation into mature M cells in organoid culture, genetic inactivation of S100a4 prevents the development of mature M cells in mice. Thus, S100A4 is a key environmental cue that regulates M cell differentiation in collaboration with RANKL."xsd:string |
| http://purl.uniprot.org/citations/31775048 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2019.10.091"xsd:string |
| http://purl.uniprot.org/citations/31775048 | http://purl.uniprot.org/core/author | "Fukui Y."xsd:string |
| http://purl.uniprot.org/citations/31775048 | http://purl.uniprot.org/core/author | "Matsubara K."xsd:string |
| http://purl.uniprot.org/citations/31775048 | http://purl.uniprot.org/core/author | "Sawa S."xsd:string |
| http://purl.uniprot.org/citations/31775048 | http://purl.uniprot.org/core/author | "Ohga S."xsd:string |
| http://purl.uniprot.org/citations/31775048 | http://purl.uniprot.org/core/author | "Shiraishi A."xsd:string |
| http://purl.uniprot.org/citations/31775048 | http://purl.uniprot.org/core/author | "Kanegane H."xsd:string |
| http://purl.uniprot.org/citations/31775048 | http://purl.uniprot.org/core/author | "Katakai T."xsd:string |
| http://purl.uniprot.org/citations/31775048 | http://purl.uniprot.org/core/author | "Uruno T."xsd:string |
| http://purl.uniprot.org/citations/31775048 | http://purl.uniprot.org/core/author | "Yoshikai Y."xsd:string |
| http://purl.uniprot.org/citations/31775048 | http://purl.uniprot.org/core/author | "Ushijima M."xsd:string |
| http://purl.uniprot.org/citations/31775048 | http://purl.uniprot.org/core/author | "Eberl G."xsd:string |
| http://purl.uniprot.org/citations/31775048 | http://purl.uniprot.org/core/author | "Sakata D."xsd:string |
| http://purl.uniprot.org/citations/31775048 | http://purl.uniprot.org/core/author | "Aihara R."xsd:string |
| http://purl.uniprot.org/citations/31775048 | http://purl.uniprot.org/core/author | "Tun X."xsd:string |
| http://purl.uniprot.org/citations/31775048 | http://purl.uniprot.org/core/author | "Kamikaseda Y."xsd:string |
| http://purl.uniprot.org/citations/31775048 | http://purl.uniprot.org/core/author | "Kunimura K."xsd:string |
| http://purl.uniprot.org/citations/31775048 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31775048 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/31775048 | http://purl.uniprot.org/core/pages | "2823-2834.e7"xsd:string |
| http://purl.uniprot.org/citations/31775048 | http://purl.uniprot.org/core/title | "S100A4 Protein Is Essential for the Development of Mature Microfold Cells in Peyer's Patches."xsd:string |
| http://purl.uniprot.org/citations/31775048 | http://purl.uniprot.org/core/volume | "29"xsd:string |
| http://purl.uniprot.org/citations/31775048 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31775048 |