| http://purl.uniprot.org/citations/31778654 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31778654 | http://www.w3.org/2000/01/rdf-schema#comment | "Although human genetic studies have implicated many susceptible genes associated with plasma lipid levels, their physiological and molecular functions are not fully characterized. Here we demonstrate that orphan G protein-coupled receptor 146 (GPR146) promotes activity of hepatic sterol regulatory element binding protein 2 (SREBP2) through activation of the extracellular signal-regulated kinase (ERK) signaling pathway, thereby regulating hepatic very low-density lipoprotein (VLDL) secretion, and subsequently circulating low-density lipoprotein cholesterol (LDL-C) and triglycerides (TG) levels. Remarkably, GPR146 deficiency reduces plasma cholesterol levels substantially in both wild-type and LDL receptor (LDLR)-deficient mice. Finally, aortic atherosclerotic lesions are reduced by 90% and 70%, respectively, in male and female LDLR-deficient mice upon GPR146 depletion. Taken together, these findings outline a regulatory role for the GPR146/ERK axis in systemic cholesterol metabolism and suggest that GPR146 inhibition could be an effective strategy to reduce plasma cholesterol levels and atherosclerosis."xsd:string |
| http://purl.uniprot.org/citations/31778654 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2019.10.034"xsd:string |
| http://purl.uniprot.org/citations/31778654 | http://purl.uniprot.org/core/author | "Chen Z."xsd:string |
| http://purl.uniprot.org/citations/31778654 | http://purl.uniprot.org/core/author | "Chen T."xsd:string |
| http://purl.uniprot.org/citations/31778654 | http://purl.uniprot.org/core/author | "Xia Y."xsd:string |
| http://purl.uniprot.org/citations/31778654 | http://purl.uniprot.org/core/author | "Yu H."xsd:string |
| http://purl.uniprot.org/citations/31778654 | http://purl.uniprot.org/core/author | "Zhao L."xsd:string |
| http://purl.uniprot.org/citations/31778654 | http://purl.uniprot.org/core/author | "Kathiresan S."xsd:string |
| http://purl.uniprot.org/citations/31778654 | http://purl.uniprot.org/core/author | "Xia F."xsd:string |
| http://purl.uniprot.org/citations/31778654 | http://purl.uniprot.org/core/author | "Cowan C.A."xsd:string |
| http://purl.uniprot.org/citations/31778654 | http://purl.uniprot.org/core/author | "Toyohara T."xsd:string |
| http://purl.uniprot.org/citations/31778654 | http://purl.uniprot.org/core/author | "Palmer A.E."xsd:string |
| http://purl.uniprot.org/citations/31778654 | http://purl.uniprot.org/core/author | "Soukas A.A."xsd:string |
| http://purl.uniprot.org/citations/31778654 | http://purl.uniprot.org/core/author | "Kuivenhoven J.A."xsd:string |
| http://purl.uniprot.org/citations/31778654 | http://purl.uniprot.org/core/author | "Kacergis M.C."xsd:string |
| http://purl.uniprot.org/citations/31778654 | http://purl.uniprot.org/core/author | "Loaiza N."xsd:string |
| http://purl.uniprot.org/citations/31778654 | http://purl.uniprot.org/core/author | "Rimbert A."xsd:string |
| http://purl.uniprot.org/citations/31778654 | http://purl.uniprot.org/core/author | "Ferreira L.M.R."xsd:string |
| http://purl.uniprot.org/citations/31778654 | http://purl.uniprot.org/core/author | "Horwitz N.B."xsd:string |
| http://purl.uniprot.org/citations/31778654 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31778654 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/31778654 | http://purl.uniprot.org/core/pages | "1276-1288.e14"xsd:string |
| http://purl.uniprot.org/citations/31778654 | http://purl.uniprot.org/core/title | "GPR146 Deficiency Protects against Hypercholesterolemia and Atherosclerosis."xsd:string |
| http://purl.uniprot.org/citations/31778654 | http://purl.uniprot.org/core/volume | "179"xsd:string |