| http://purl.uniprot.org/citations/31787756 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31787756 | http://www.w3.org/2000/01/rdf-schema#comment | "Endoplasmic reticulum (ER) stress signaling plays a critical role in the control of cell survival or death. Persistent ER stress activates proapoptotic pathway involving the ATF4/CHOP axis. Although accumulating evidences support its important contribution to cardiovascular diseases, but its mechanism is not well characterized. Here, we demonstrate a critical role for PRMT1 in the control of ER stress in cardiomyocytes. The inhibition of PRMT1 augments tunicamycin (TN)-triggered ER stress response in cardiomyocytes while PRMT1 overexpression attenuates it. Consistently, PRMT1 null hearts show exacerbated ER stress and cell death in response to TN treatment. Interestingly, ATF4 depletion attenuates the ER stress response induced by PRMT1 inhibition. The methylation-deficient mutant of ATF4 with the switch of arginine 239 to lysine exacerbates ER stress accompanied by enhanced levels of proapoptotic cleaved Caspase3 and phosphorylated-γH2AX in response to TN. The mechanistic study shows that PRMT1 modulates the protein stability of ATF4 through methylation. Taken together, our data suggest that ATF4 methylation on arginine 239 by PRMT1 is a novel regulatory mechanism for protection of cardiomyocytes from ER stress-induced cell death."xsd:string |
| http://purl.uniprot.org/citations/31787756 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41419-019-2147-3"xsd:string |
| http://purl.uniprot.org/citations/31787756 | http://purl.uniprot.org/core/author | "Jeong H.J."xsd:string |
| http://purl.uniprot.org/citations/31787756 | http://purl.uniprot.org/core/author | "Ahn B.Y."xsd:string |
| http://purl.uniprot.org/citations/31787756 | http://purl.uniprot.org/core/author | "Cho H."xsd:string |
| http://purl.uniprot.org/citations/31787756 | http://purl.uniprot.org/core/author | "Kang J.S."xsd:string |
| http://purl.uniprot.org/citations/31787756 | http://purl.uniprot.org/core/author | "Kwon I."xsd:string |
| http://purl.uniprot.org/citations/31787756 | http://purl.uniprot.org/core/author | "Jeong M.H."xsd:string |
| http://purl.uniprot.org/citations/31787756 | http://purl.uniprot.org/core/author | "Pyun J.H."xsd:string |
| http://purl.uniprot.org/citations/31787756 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31787756 | http://purl.uniprot.org/core/name | "Cell Death Dis"xsd:string |
| http://purl.uniprot.org/citations/31787756 | http://purl.uniprot.org/core/pages | "903"xsd:string |
| http://purl.uniprot.org/citations/31787756 | http://purl.uniprot.org/core/title | "PRMT1 suppresses ATF4-mediated endoplasmic reticulum response in cardiomyocytes."xsd:string |
| http://purl.uniprot.org/citations/31787756 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/31787756 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31787756 |
| http://purl.uniprot.org/citations/31787756 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31787756 |
| http://purl.uniprot.org/uniprot/#_A0A140LHF7-mappedCitation-31787756 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31787756 |
| http://purl.uniprot.org/uniprot/#_A0A140LHS4-mappedCitation-31787756 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31787756 |
| http://purl.uniprot.org/uniprot/#_A0A140LI33-mappedCitation-31787756 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31787756 |
| http://purl.uniprot.org/uniprot/#_A0A140LIF7-mappedCitation-31787756 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31787756 |
| http://purl.uniprot.org/uniprot/#_A0A140LJ68-mappedCitation-31787756 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31787756 |
| http://purl.uniprot.org/uniprot/#_A0A140LJ70-mappedCitation-31787756 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31787756 |
| http://purl.uniprot.org/uniprot/#_A0A140LJF4-mappedCitation-31787756 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31787756 |
| http://purl.uniprot.org/uniprot/#_A0A140LJG1-mappedCitation-31787756 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31787756 |