| http://purl.uniprot.org/citations/31806368 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31806368 | http://www.w3.org/2000/01/rdf-schema#comment | "Upon invading the cell, the viral RNA is recognized by the RIG-I receptor located in the cytoplasm, causing the RIG-I receptor to be activated. The activated RIG-I receptor transmits downstream antiviral signals by interacting with the adaptor protein VISA located on the mitochondria, leading to the production of type Ⅰ interferons and crude inflammatory cytokine genes. Although there have been many studies on antiviral signal transduction of RIG-I receptors in recent years, the mechanism of RIG-I-VISA-mediated antiviral regulation is still not fully understood. In this study, we identified SNX5 as a negative regulator of RLR-mediated antiviral signaling. Our results show that overexpression of SNX5 inhibits viral-induced activation of the IFN-β promoter, ISRE, NF-κB, and IRF3, whereas RNAi knockdown of SNX5 expression shows opposite results. We also found that overexpression of SNX5 enhanced RIG-I's K48 ubiquitination and attenuated its K63 ubiquitination, resulting in inhibition of virus-induced RIG-I expression. Besides, further studies show that SNX5 overexpression weakens the interaction between VISA and TRAF2/5. Our findings suggest that SNX5 negatively regulates RLR-mediated antiviral signaling by targeting the RIG-I-VISA signalosome and provide new evidence for the negative regulation of RIG-I-mediated innate immune response mechanisms."xsd:string |
| http://purl.uniprot.org/citations/31806368 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2019.11.121"xsd:string |
| http://purl.uniprot.org/citations/31806368 | http://purl.uniprot.org/core/author | "Chen T."xsd:string |
| http://purl.uniprot.org/citations/31806368 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/31806368 | http://purl.uniprot.org/core/author | "Xie T."xsd:string |
| http://purl.uniprot.org/citations/31806368 | http://purl.uniprot.org/core/author | "Yang Y.X."xsd:string |
| http://purl.uniprot.org/citations/31806368 | http://purl.uniprot.org/core/author | "Xu L.G."xsd:string |
| http://purl.uniprot.org/citations/31806368 | http://purl.uniprot.org/core/author | "He T.S."xsd:string |
| http://purl.uniprot.org/citations/31806368 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/31806368 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/31806368 | http://purl.uniprot.org/core/pages | "889-896"xsd:string |
| http://purl.uniprot.org/citations/31806368 | http://purl.uniprot.org/core/title | "SNX5 inhibits RLR-mediated antiviral signaling by targeting RIG-I-VISA signalosome."xsd:string |
| http://purl.uniprot.org/citations/31806368 | http://purl.uniprot.org/core/volume | "522"xsd:string |
| http://purl.uniprot.org/citations/31806368 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31806368 |
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