| http://purl.uniprot.org/citations/31808541 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31808541 | http://www.w3.org/2000/01/rdf-schema#comment | "Dysfunction of FOXP3-positive regulatory T cells (Tregs) likely plays a major role in the pathogenesis of multiple autoimmune diseases including type 1 diabetes (T1D). Whether genetic polymorphisms associated with the risk of autoimmune diseases affect Treg frequency or function is currently unclear. Here, we analysed the effect of T1D-associated major HLA class II haplotypes and seven single nucleotide polymorphisms in six non-HLA genes [INS (rs689), PTPN22 (rs2476601), IL2RA (rs12722495 and rs2104286), PTPN2 (rs45450798), CTLA4 (rs3087243), and ERBB3 (rs2292239)] on peripheral blood Treg frequencies. These were determined by flow cytometry in 65 subjects who had progressed to T1D, 86 islet autoantibody-positive at-risk subjects, and 215 islet autoantibody-negative healthy controls. The PTPN22 rs2476601 risk allele A was associated with an increase in total (p = 6 × 10-6 ) and naïve (p = 4 × 10-5 ) CD4+CD25+CD127lowFOXP3+ Treg frequencies. These findings were validated in a separate cohort comprising ten trios of healthy islet autoantibody-negative children carrying each of the three PTPN22 rs2476601 genotypes AA, AG, and GG (p = 0.005 for total and p = 0.03 for naïve Tregs, respectively). In conclusion, our analysis implicates the autoimmune PTPN22 rs2476601 risk allele A in controlling the frequency of Tregs in human peripheral blood."xsd:string |
| http://purl.uniprot.org/citations/31808541 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.201948378"xsd:string |
| http://purl.uniprot.org/citations/31808541 | http://purl.uniprot.org/core/author | "Toppari J."xsd:string |
| http://purl.uniprot.org/citations/31808541 | http://purl.uniprot.org/core/author | "Knip M."xsd:string |
| http://purl.uniprot.org/citations/31808541 | http://purl.uniprot.org/core/author | "Kinnunen T."xsd:string |
| http://purl.uniprot.org/citations/31808541 | http://purl.uniprot.org/core/author | "Ilonen J."xsd:string |
| http://purl.uniprot.org/citations/31808541 | http://purl.uniprot.org/core/author | "Veijola R."xsd:string |
| http://purl.uniprot.org/citations/31808541 | http://purl.uniprot.org/core/author | "Lempainen J."xsd:string |
| http://purl.uniprot.org/citations/31808541 | http://purl.uniprot.org/core/author | "Valta M."xsd:string |
| http://purl.uniprot.org/citations/31808541 | http://purl.uniprot.org/core/author | "Ekman I."xsd:string |
| http://purl.uniprot.org/citations/31808541 | http://purl.uniprot.org/core/author | "Gazali A.M."xsd:string |
| http://purl.uniprot.org/citations/31808541 | http://purl.uniprot.org/core/author | "Ihantola E.L."xsd:string |
| http://purl.uniprot.org/citations/31808541 | http://purl.uniprot.org/core/author | "Viisanen T."xsd:string |
| http://purl.uniprot.org/citations/31808541 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/31808541 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/31808541 | http://purl.uniprot.org/core/pages | "581-588"xsd:string |
| http://purl.uniprot.org/citations/31808541 | http://purl.uniprot.org/core/title | "Type 1 diabetes linked PTPN22 gene polymorphism is associated with the frequency of circulating regulatory T cells."xsd:string |
| http://purl.uniprot.org/citations/31808541 | http://purl.uniprot.org/core/volume | "50"xsd:string |
| http://purl.uniprot.org/citations/31808541 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31808541 |
| http://purl.uniprot.org/citations/31808541 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31808541 |
| http://purl.uniprot.org/uniprot/#_A0A0B4J1S7-mappedCitation-31808541 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31808541 |
| http://purl.uniprot.org/uniprot/#_A0A1Q2XD95-mappedCitation-31808541 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31808541 |
| http://purl.uniprot.org/uniprot/#_A0A1Q2XDC9-mappedCitation-31808541 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31808541 |
| http://purl.uniprot.org/uniprot/#_A0A1S6KJG4-mappedCitation-31808541 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31808541 |