| http://purl.uniprot.org/citations/31808745 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31808745 | http://www.w3.org/2000/01/rdf-schema#comment | "Heterogeneity of lymphatic vessels during embryogenesis is critical for organ-specific lymphatic function. Little is known about lymphatics in the developing kidney, despite their established roles in pathology of the mature organ. We performed three-dimensional imaging to characterize lymphatic vessel formation in the mammalian embryonic kidney at single-cell resolution. In mouse, we visually and quantitatively assessed the development of kidney lymphatic vessels, remodeling from a ring-like anastomosis under the nascent renal pelvis; a site of VEGF-C expression, to form a patent vascular plexus. We identified a heterogenous population of lymphatic endothelial cell clusters in mouse and human embryonic kidneys. Exogenous VEGF-C expanded the lymphatic population in explanted mouse embryonic kidneys. Finally, we characterized complex kidney lymphatic abnormalities in a genetic mouse model of polycystic kidney disease. Our study provides novel insights into the development of kidney lymphatic vasculature; a system which likely has fundamental roles in renal development, physiology and disease."xsd:string |
| http://purl.uniprot.org/citations/31808745 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.48183"xsd:string |
| http://purl.uniprot.org/citations/31808745 | http://purl.uniprot.org/core/author | "Harris P.C."xsd:string |
| http://purl.uniprot.org/citations/31808745 | http://purl.uniprot.org/core/author | "Woolf A.S."xsd:string |
| http://purl.uniprot.org/citations/31808745 | http://purl.uniprot.org/core/author | "Scambler P.J."xsd:string |
| http://purl.uniprot.org/citations/31808745 | http://purl.uniprot.org/core/author | "Correra R.M."xsd:string |
| http://purl.uniprot.org/citations/31808745 | http://purl.uniprot.org/core/author | "Kolatsi-Joannou M."xsd:string |
| http://purl.uniprot.org/citations/31808745 | http://purl.uniprot.org/core/author | "Long D.A."xsd:string |
| http://purl.uniprot.org/citations/31808745 | http://purl.uniprot.org/core/author | "Ruhrberg C."xsd:string |
| http://purl.uniprot.org/citations/31808745 | http://purl.uniprot.org/core/author | "Riley P.R."xsd:string |
| http://purl.uniprot.org/citations/31808745 | http://purl.uniprot.org/core/author | "Moulding D."xsd:string |
| http://purl.uniprot.org/citations/31808745 | http://purl.uniprot.org/core/author | "Winyard P.J."xsd:string |
| http://purl.uniprot.org/citations/31808745 | http://purl.uniprot.org/core/author | "Price K.L."xsd:string |
| http://purl.uniprot.org/citations/31808745 | http://purl.uniprot.org/core/author | "Walker-Samuel S."xsd:string |
| http://purl.uniprot.org/citations/31808745 | http://purl.uniprot.org/core/author | "Jafree D.J."xsd:string |
| http://purl.uniprot.org/citations/31808745 | http://purl.uniprot.org/core/author | "Milmoe N.J."xsd:string |
| http://purl.uniprot.org/citations/31808745 | http://purl.uniprot.org/core/author | "Perretta Tejedor N."xsd:string |
| http://purl.uniprot.org/citations/31808745 | http://purl.uniprot.org/core/author | "Walsh C.L."xsd:string |
| http://purl.uniprot.org/citations/31808745 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31808745 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/31808745 | http://purl.uniprot.org/core/pages | "e48183"xsd:string |
| http://purl.uniprot.org/citations/31808745 | http://purl.uniprot.org/core/title | "Spatiotemporal dynamics and heterogeneity of renal lymphatics in mammalian development and cystic kidney disease."xsd:string |
| http://purl.uniprot.org/citations/31808745 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/31808745 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31808745 |