http://purl.uniprot.org/citations/31811152 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/31811152 | http://www.w3.org/2000/01/rdf-schema#comment | "Pairing of homologous chromosomes in meiosis is essential for sexual reproduction. We have previously demonstrated that the fission yeast sme2 RNA, a meiosis-specific long noncoding RNA (lncRNA), accumulates at the sme2 chromosomal loci and mediates their robust pairing in meiosis. However, the mechanisms underlying lncRNA-mediated homologous pairing have remained elusive. In this study, we identify conserved RNA-binding proteins that are required for robust pairing of homologous chromosomes. These proteins accumulate mainly at the sme2 and two other chromosomal loci together with meiosis-specific lncRNAs transcribed from these loci. Remarkably, the chromosomal accumulation of these lncRNA-protein complexes is required for robust pairing. Moreover, the lncRNA-protein complexes exhibit phase separation properties, since 1,6-hexanediol treatment reversibly disassembled these complexes and disrupted the pairing of associated loci. We propose that lncRNA-protein complexes assembled at specific chromosomal loci mediate recognition and subsequent pairing of homologous chromosomes."xsd:string |
http://purl.uniprot.org/citations/31811152 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-019-13609-0"xsd:string |
http://purl.uniprot.org/citations/31811152 | http://purl.uniprot.org/core/author | "Haraguchi T."xsd:string |
http://purl.uniprot.org/citations/31811152 | http://purl.uniprot.org/core/author | "Shirahige K."xsd:string |
http://purl.uniprot.org/citations/31811152 | http://purl.uniprot.org/core/author | "Chikashige Y."xsd:string |
http://purl.uniprot.org/citations/31811152 | http://purl.uniprot.org/core/author | "Hiraoka Y."xsd:string |
http://purl.uniprot.org/citations/31811152 | http://purl.uniprot.org/core/author | "Katou Y."xsd:string |
http://purl.uniprot.org/citations/31811152 | http://purl.uniprot.org/core/author | "Oya E."xsd:string |
http://purl.uniprot.org/citations/31811152 | http://purl.uniprot.org/core/author | "Okamasa K."xsd:string |
http://purl.uniprot.org/citations/31811152 | http://purl.uniprot.org/core/author | "Nakayama J.I."xsd:string |
http://purl.uniprot.org/citations/31811152 | http://purl.uniprot.org/core/author | "Ding D.Q."xsd:string |
http://purl.uniprot.org/citations/31811152 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
http://purl.uniprot.org/citations/31811152 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
http://purl.uniprot.org/citations/31811152 | http://purl.uniprot.org/core/pages | "5598"xsd:string |
http://purl.uniprot.org/citations/31811152 | http://purl.uniprot.org/core/title | "Chromosome-associated RNA-protein complexes promote pairing of homologous chromosomes during meiosis in Schizosaccharomyces pombe."xsd:string |
http://purl.uniprot.org/citations/31811152 | http://purl.uniprot.org/core/volume | "10"xsd:string |
http://purl.uniprot.org/citations/31811152 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31811152 |
http://purl.uniprot.org/citations/31811152 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31811152 |
http://purl.uniprot.org/uniprot/O43040#attribution-D8245B71F485498035B91D9692865CA5 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/31811152 |
http://purl.uniprot.org/uniprot/Q10295#attribution-D8245B71F485498035B91D9692865CA5 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/31811152 |
http://purl.uniprot.org/uniprot/O14327#attribution-D8245B71F485498035B91D9692865CA5 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/31811152 |
http://purl.uniprot.org/uniprot/Q92368#attribution-D8245B71F485498035B91D9692865CA5 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/31811152 |
http://purl.uniprot.org/uniprot/Q9UTE3#attribution-D8245B71F485498035B91D9692865CA5 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/31811152 |
http://purl.uniprot.org/uniprot/Q10237#attribution-D8245B71F485498035B91D9692865CA5 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/31811152 |