| http://purl.uniprot.org/citations/31836707 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31836707 | http://www.w3.org/2000/01/rdf-schema#comment | "The macromolecular machines of life use allosteric control to self-assemble, dissociate and change shape in response to signals. Despite enormous interest, the design of nanoscale allosteric assemblies has proven tremendously challenging. Here we present a proof of concept of allosteric assembly in which an engineered fold switch on the protein monomer triggers or blocks assembly. Our design is based on the hyper-stable, naturally monomeric protein CI2, a paradigm of simple two-state folding, and the toroidal arrangement with 6-fold symmetry that it only adopts in crystalline form. We engineer CI2 to enable a switch between the native and an alternate, latent fold that self-assembles onto hexagonal toroidal particles by exposing a favorable inter-monomer interface. The assembly is controlled on demand via the competing effects of temperature and a designed short peptide. These findings unveil a remarkable potential for structural metamorphosis in proteins and demonstrate key principles for engineering protein-based nanomachinery."xsd:string |
| http://purl.uniprot.org/citations/31836707 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-019-13686-1"xsd:string |
| http://purl.uniprot.org/citations/31836707 | http://purl.uniprot.org/core/author | "Sharma R."xsd:string |
| http://purl.uniprot.org/citations/31836707 | http://purl.uniprot.org/core/author | "Valpuesta J.M."xsd:string |
| http://purl.uniprot.org/citations/31836707 | http://purl.uniprot.org/core/author | "Alfonso C."xsd:string |
| http://purl.uniprot.org/citations/31836707 | http://purl.uniprot.org/core/author | "Rivas G."xsd:string |
| http://purl.uniprot.org/citations/31836707 | http://purl.uniprot.org/core/author | "Ruiz F.M."xsd:string |
| http://purl.uniprot.org/citations/31836707 | http://purl.uniprot.org/core/author | "Munoz V."xsd:string |
| http://purl.uniprot.org/citations/31836707 | http://purl.uniprot.org/core/author | "Alvira S."xsd:string |
| http://purl.uniprot.org/citations/31836707 | http://purl.uniprot.org/core/author | "Campos L.A."xsd:string |
| http://purl.uniprot.org/citations/31836707 | http://purl.uniprot.org/core/author | "Sanchez-Ruiz J.M."xsd:string |
| http://purl.uniprot.org/citations/31836707 | http://purl.uniprot.org/core/author | "Ibarra-Molero B."xsd:string |
| http://purl.uniprot.org/citations/31836707 | http://purl.uniprot.org/core/author | "Sadqi M."xsd:string |
| http://purl.uniprot.org/citations/31836707 | http://purl.uniprot.org/core/author | "Romero Garrido A."xsd:string |
| http://purl.uniprot.org/citations/31836707 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31836707 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/31836707 | http://purl.uniprot.org/core/pages | "5703"xsd:string |
| http://purl.uniprot.org/citations/31836707 | http://purl.uniprot.org/core/title | "Engineering protein assemblies with allosteric control via monomer fold-switching."xsd:string |
| http://purl.uniprot.org/citations/31836707 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/31836707 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31836707 |
| http://purl.uniprot.org/citations/31836707 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31836707 |
| http://purl.uniprot.org/uniprot/#_P01053-mappedCitation-31836707 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31836707 |
| http://purl.uniprot.org/uniprot/P01053 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/31836707 |