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http://purl.uniprot.org/citations/31840157http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/31840157http://www.w3.org/2000/01/rdf-schema#comment"

Background

Interleukin-11 (IL-11) is a pleiotropic cytokine of the interleukin-6 family. Recent studies revealed its crucial role in the development of cardiovascular fibrosis. In this study we examined IL-11 expression levels in the heart and the kidney exposed to high blood pressure in renovascular hypertensive rats and their correlations to fibrotic markers and kidney injury.

Methods

Two-kidney, one-clip renovascular hypertension (2K1C) was induced in rats. IL-11 expression was measured by real-time polymerase chain reaction in the left ventricle and the right kidney. The correlation of cardiac IL-11 expression with biomarkers of renal fibrosis was assessed. We further investigated IL-11 expression in 2K1C rats grouped into rats with malignant vs. nonmalignant hypertension (distinguishing criteria: weight loss, number of fibrinoid necrosis, and onion skin lesions).

Results

Thirty-five days after clipping, mean arterial pressure was significantly increased in 2K1C. Renal IL-11 expression was elevated in 2K1C. In the heart there was only a trend toward higher IL-11 expression in 2K1C. IL-11 in the kidney in 2K1C correlated with the expression of transforming growth factor (TGF)-β1/2, collagens, fibronectin, osteopontin, as well as tissue inhibitors of metalloprotease 1/2. There were also correlations of IL-11 with tissue collagen expansion, number of activated fibroblasts and serum creatinine, but no correlation with mean arterial pressure. Renal expression of IL-11 was highest in rats with malignant hypertension.

Conclusions

Renal IL-11 expression of renovascular hypertensive rats is markedly increased and correlates with profibrotic markers and loss of function and might therefore serve as a biomarker for the severity of hypertensive nephrosclerosis."xsd:string
http://purl.uniprot.org/citations/31840157http://purl.org/dc/terms/identifier"doi:10.1093/ajh/hpz194"xsd:string
http://purl.uniprot.org/citations/31840157http://purl.uniprot.org/core/author"Amann K."xsd:string
http://purl.uniprot.org/citations/31840157http://purl.uniprot.org/core/author"Hilgers K.F."xsd:string
http://purl.uniprot.org/citations/31840157http://purl.uniprot.org/core/author"Cordasic N."xsd:string
http://purl.uniprot.org/citations/31840157http://purl.uniprot.org/core/author"Hartner A."xsd:string
http://purl.uniprot.org/citations/31840157http://purl.uniprot.org/core/author"Veelken R."xsd:string
http://purl.uniprot.org/citations/31840157http://purl.uniprot.org/core/author"Menendez-Castro C."xsd:string
http://purl.uniprot.org/citations/31840157http://purl.uniprot.org/core/author"Dambietz T."xsd:string
http://purl.uniprot.org/citations/31840157http://purl.uniprot.org/core/date"2020"xsd:gYear
http://purl.uniprot.org/citations/31840157http://purl.uniprot.org/core/name"Am J Hypertens"xsd:string
http://purl.uniprot.org/citations/31840157http://purl.uniprot.org/core/pages"331-340"xsd:string
http://purl.uniprot.org/citations/31840157http://purl.uniprot.org/core/title"Correlations Between Interleukin-11 Expression and Hypertensive Kidney Injury in a Rat Model of Renovascular Hypertension."xsd:string
http://purl.uniprot.org/citations/31840157http://purl.uniprot.org/core/volume"33"xsd:string
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