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http://purl.uniprot.org/citations/31841189http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/31841189http://www.w3.org/2000/01/rdf-schema#comment"

Objective

Increasing studies indicated that long non-coding RNA (lncRNA) has crucial roles in cancer development, including non-small cell lung cancer (NSCLC). LINC02418 was reported to promote colorectal cancer development. However, whether LINC02418 has a role in NSCLC remains to be explored.

Materials and methods

First, expression level of LINC02418 in NSCLC tissues and normal tissues was analyzed at ENCORI. Moreover, expression level of LINC02418 in NSCLC cells and normal cell was analyzed with quantitative real-time PCR. Cell counting kit-8 assay, transwell invasion assay, and flow cytometry assay were used to analyze cell proliferation, cell invasion, and cell apoptosis.

Results

LINC02418 was found as upregulated expression in both NSCLC tissues and cells. Functional assays showed that LINC02418 knockdown suppressed NSCLC cell proliferation and invasion but promoted cell apoptosis, while the overexpression of LINC02418 exerts opposite effects. Mechanistically, we showed LINC02418 could interact with microRNA-4677-3p (miR-4677-3p) to regulate Sec61 gamma subunit (SEC61G) expression.

Conclusions

These results indicated that LINC02418 functions as an oncogene, and regulated miR-4677-3p/SEC61G axis to accelerate NSCLC progression."xsd:string
http://purl.uniprot.org/citations/31841189http://purl.org/dc/terms/identifier"doi:10.26355/eurrev_201912_19673"xsd:string
http://purl.uniprot.org/citations/31841189http://purl.uniprot.org/core/author"Han B."xsd:string
http://purl.uniprot.org/citations/31841189http://purl.uniprot.org/core/date"2019"xsd:gYear
http://purl.uniprot.org/citations/31841189http://purl.uniprot.org/core/name"Eur Rev Med Pharmacol Sci"xsd:string
http://purl.uniprot.org/citations/31841189http://purl.uniprot.org/core/pages"10354-10362"xsd:string
http://purl.uniprot.org/citations/31841189http://purl.uniprot.org/core/title"LncRNA LINC02418 regulates proliferation and apoptosis of non-small cell lung cancer cells by regulating miR-4677-3p/SEC61G."xsd:string
http://purl.uniprot.org/citations/31841189http://purl.uniprot.org/core/volume"23"xsd:string
http://purl.uniprot.org/citations/31841189http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/31841189
http://purl.uniprot.org/citations/31841189http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/31841189
http://purl.uniprot.org/uniprot/#_P60059-mappedCitation-31841189http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/31841189
http://purl.uniprot.org/uniprot/#_Q6ZS53-mappedCitation-31841189http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/31841189
http://purl.uniprot.org/uniprot/#_Q6ZT71-mappedCitation-31841189http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/31841189
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http://purl.uniprot.org/uniprot/P60059http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/31841189
http://purl.uniprot.org/uniprot/Q6ZS53http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/31841189