| http://purl.uniprot.org/citations/31843195 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31843195 | http://www.w3.org/2000/01/rdf-schema#comment | "Although circulating leukocytes are non-adherent cells, they also undergo adhesion in response to external stimuli. To elucidate this switch mechanism, we investigated PMA-induced cell adhesion in myelomonocytic KG-1 cells. PMA induced microvillius collapse, decrease of cell surface rigidity and exclusion of sialomucin from adhesion sites. All these adhesion-contributing events are linked to dephosphorylation of Ezrin/Radixin/Moesin (ERM) proteins. Indeed, PMA-treatment induced quick decrease of phosphorylated ERM proteins, while expression of Moesin-T558D, a phospho-mimetic mutant, inhibited PMA-induced cell adhesion. PMA-induced cell adhesion and ERM-dephophorylation were inhibited by PKC inhibitors or by a phosphatase inhibitor, indicating the involvement of PKC and protein phophatase in these processes. In peripheral T lymphocytes, ERM-dephosphorylation by adhesion-inducing stimuli was inhibited by a PKC inhibitor. Combined, these findings strongly suggest that external stimuli induce ERM-dephosphorylation via the activation of PKC in leukocytes and that ERM-dephosphorylation leads to leukocytes' adhesion."xsd:string |
| http://purl.uniprot.org/citations/31843195 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2019.12.044"xsd:string |
| http://purl.uniprot.org/citations/31843195 | http://purl.uniprot.org/core/author | "Ohnishi H."xsd:string |
| http://purl.uniprot.org/citations/31843195 | http://purl.uniprot.org/core/author | "Tachibana K."xsd:string |
| http://purl.uniprot.org/citations/31843195 | http://purl.uniprot.org/core/author | "Kihara T."xsd:string |
| http://purl.uniprot.org/citations/31843195 | http://purl.uniprot.org/core/author | "Miyake J."xsd:string |
| http://purl.uniprot.org/citations/31843195 | http://purl.uniprot.org/core/author | "Ali Haghparast S.M."xsd:string |
| http://purl.uniprot.org/citations/31843195 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/31843195 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/31843195 | http://purl.uniprot.org/core/pages | "177-182"xsd:string |
| http://purl.uniprot.org/citations/31843195 | http://purl.uniprot.org/core/title | "Activation of PKC induces leukocyte adhesion by the dephosphorylation of ERM."xsd:string |
| http://purl.uniprot.org/citations/31843195 | http://purl.uniprot.org/core/volume | "523"xsd:string |
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