| http://purl.uniprot.org/citations/31845480 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31845480 | http://www.w3.org/2000/01/rdf-schema#comment | "WW domain binding protein 1-like (WBP1L), also known as outcome predictor of acute leukaemia 1 (OPAL1), is a transmembrane adaptor protein, expression of which correlates with ETV6-RUNX1 (t(12;21)(p13;q22)) translocation and favourable prognosis in childhood leukaemia. It has a broad expression pattern in haematopoietic and in non-haematopoietic cells. However, its physiological function has been unknown. Here, we show that WBP1L negatively regulates signalling through a critical chemokine receptor CXCR4 in multiple leucocyte subsets and cell lines. We also show that WBP1L interacts with NEDD4-family ubiquitin ligases and regulates CXCR4 ubiquitination and expression. Moreover, analysis of Wbp1l-deficient mice revealed alterations in B cell development and enhanced efficiency of bone marrow cell transplantation. Collectively, our data show that WBP1L is a novel regulator of CXCR4 signalling and haematopoiesis."xsd:string |
| http://purl.uniprot.org/citations/31845480 | http://purl.org/dc/terms/identifier | "doi:10.1111/jcmm.14895"xsd:string |
| http://purl.uniprot.org/citations/31845480 | http://purl.uniprot.org/core/author | "Tomlinson M.G."xsd:string |
| http://purl.uniprot.org/citations/31845480 | http://purl.uniprot.org/core/author | "Kralova J."xsd:string |
| http://purl.uniprot.org/citations/31845480 | http://purl.uniprot.org/core/author | "Korinek V."xsd:string |
| http://purl.uniprot.org/citations/31845480 | http://purl.uniprot.org/core/author | "Angelisova P."xsd:string |
| http://purl.uniprot.org/citations/31845480 | http://purl.uniprot.org/core/author | "Brdicka T."xsd:string |
| http://purl.uniprot.org/citations/31845480 | http://purl.uniprot.org/core/author | "Skopcova T."xsd:string |
| http://purl.uniprot.org/citations/31845480 | http://purl.uniprot.org/core/author | "Fabisik M."xsd:string |
| http://purl.uniprot.org/citations/31845480 | http://purl.uniprot.org/core/author | "Pokorna J."xsd:string |
| http://purl.uniprot.org/citations/31845480 | http://purl.uniprot.org/core/author | "Kwiatkowska K."xsd:string |
| http://purl.uniprot.org/citations/31845480 | http://purl.uniprot.org/core/author | "Starkova J."xsd:string |
| http://purl.uniprot.org/citations/31845480 | http://purl.uniprot.org/core/author | "Alberich-Jorda M."xsd:string |
| http://purl.uniprot.org/citations/31845480 | http://purl.uniprot.org/core/author | "Borna S."xsd:string |
| http://purl.uniprot.org/citations/31845480 | http://purl.uniprot.org/core/author | "Kanderova V."xsd:string |
| http://purl.uniprot.org/citations/31845480 | http://purl.uniprot.org/core/author | "Drobek A."xsd:string |
| http://purl.uniprot.org/citations/31845480 | http://purl.uniprot.org/core/author | "Protty M.B."xsd:string |
| http://purl.uniprot.org/citations/31845480 | http://purl.uniprot.org/core/author | "Splichalova I."xsd:string |
| http://purl.uniprot.org/citations/31845480 | http://purl.uniprot.org/core/author | "Glatzova D."xsd:string |
| http://purl.uniprot.org/citations/31845480 | http://purl.uniprot.org/core/author | "Matveichuk O.V."xsd:string |
| http://purl.uniprot.org/citations/31845480 | http://purl.uniprot.org/core/author | "Pavliuchenko N."xsd:string |
| http://purl.uniprot.org/citations/31845480 | http://purl.uniprot.org/core/author | "Stanek P."xsd:string |
| http://purl.uniprot.org/citations/31845480 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/31845480 | http://purl.uniprot.org/core/name | "J Cell Mol Med"xsd:string |