| http://purl.uniprot.org/citations/31848151 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31848151 | http://www.w3.org/2000/01/rdf-schema#comment | "Loss of functional β-cell mass is an essential feature of type 2 diabetes, and maintaining mature β-cell identity is important for preserving a functional β-cell mass. However, it is unclear how β-cells achieve and maintain their mature identity. Here we demonstrate a novel function of protein arginine methyltransferase 1 (PRMT1) in maintaining mature β-cell identity. Prmt1 knockout in fetal and adult β-cells induced diabetes, which was aggravated by high-fat diet-induced metabolic stress. Deletion of Prmt1 in adult β-cells resulted in the immediate loss of histone H4 arginine 3 asymmetric dimethylation (H4R3me2a) and the subsequent loss of β-cell identity. The expression levels of genes involved in mature β-cell function and identity were robustly downregulated as soon as Prmt1 deletion was induced in adult β-cells. Chromatin immunoprecipitation sequencing and assay for transposase-accessible chromatin sequencing analyses revealed that PRMT1-dependent H4R3me2a increases chromatin accessibility at the binding sites for CCCTC-binding factor (CTCF) and β-cell transcription factors. In addition, PRMT1-dependent open chromatin regions may show an association with the risk of diabetes in humans. Together, our results indicate that PRMT1 plays an essential role in maintaining β-cell identity by regulating chromatin accessibility."xsd:string |
| http://purl.uniprot.org/citations/31848151 | http://purl.org/dc/terms/identifier | "doi:10.2337/db19-0685"xsd:string |
| http://purl.uniprot.org/citations/31848151 | http://purl.uniprot.org/core/author | "Kim E."xsd:string |
| http://purl.uniprot.org/citations/31848151 | http://purl.uniprot.org/core/author | "Kim M."xsd:string |
| http://purl.uniprot.org/citations/31848151 | http://purl.uniprot.org/core/author | "Kim H."xsd:string |
| http://purl.uniprot.org/citations/31848151 | http://purl.uniprot.org/core/author | "Kim H.J."xsd:string |
| http://purl.uniprot.org/citations/31848151 | http://purl.uniprot.org/core/author | "Lee J."xsd:string |
| http://purl.uniprot.org/citations/31848151 | http://purl.uniprot.org/core/author | "Kim S."xsd:string |
| http://purl.uniprot.org/citations/31848151 | http://purl.uniprot.org/core/author | "Lee K."xsd:string |
| http://purl.uniprot.org/citations/31848151 | http://purl.uniprot.org/core/author | "Song H."xsd:string |
| http://purl.uniprot.org/citations/31848151 | http://purl.uniprot.org/core/author | "Kim Y.K."xsd:string |
| http://purl.uniprot.org/citations/31848151 | http://purl.uniprot.org/core/author | "Kim M.Y."xsd:string |
| http://purl.uniprot.org/citations/31848151 | http://purl.uniprot.org/core/author | "Shong M."xsd:string |
| http://purl.uniprot.org/citations/31848151 | http://purl.uniprot.org/core/author | "Lee J.'"xsd:string |
| http://purl.uniprot.org/citations/31848151 | http://purl.uniprot.org/core/author | "Yi K."xsd:string |
| http://purl.uniprot.org/citations/31848151 | http://purl.uniprot.org/core/author | "Kim H.'"xsd:string |
| http://purl.uniprot.org/citations/31848151 | http://purl.uniprot.org/core/author | "Koo S.H."xsd:string |
| http://purl.uniprot.org/citations/31848151 | http://purl.uniprot.org/core/author | "Seong J.K."xsd:string |
| http://purl.uniprot.org/citations/31848151 | http://purl.uniprot.org/core/author | "Suh J.M."xsd:string |
| http://purl.uniprot.org/citations/31848151 | http://purl.uniprot.org/core/author | "Yoon B.H."xsd:string |
| http://purl.uniprot.org/citations/31848151 | http://purl.uniprot.org/core/author | "Heo H."xsd:string |
| http://purl.uniprot.org/citations/31848151 | http://purl.uniprot.org/core/author | "Oh C.M."xsd:string |
| http://purl.uniprot.org/citations/31848151 | http://purl.uniprot.org/core/author | "Ju Y.S."xsd:string |
| http://purl.uniprot.org/citations/31848151 | http://purl.uniprot.org/core/author | "Kim H.''"xsd:string |