| http://purl.uniprot.org/citations/31864704 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31864704 | http://www.w3.org/2000/01/rdf-schema#comment | "Knockdown of THG-1 in TE13 esophageal squamous cell carcinoma (ESCC) cells is known to suppress tumorsphere growth. THG-1 was identified as an NRBP1 binding protein, and NRBP1 was reported to downregulate an stemness-related transcriptional factor SALL4, so we decided to examine the possibility that tumorigenic function of THG-1 is achieved by the competition to the tumor-suppressive function of NRBP1. SALL4 was decreased in THG-1 deficient TE13 cells with reduced tumorsphere formation, while exogenous SALL4 expression in THG-1 deficient TE13 cells recovered expression of stemness genes (NANOG and OCT4) and partially, but significantly, recovered tumorsphere formation ability. Additionally, we found that NRBP1 induced ubiquitination of SALL4, and THG-1 interrupted the ubiquitination of SALL4 by antagonizing NRBP1 binding to SALL4. These results suggest that THG-1 promotes tumorsphere growth of ESCC cells by the stabilization of SALL4 protein and induction of the target stemness genes through competitive binding to NRBP1."xsd:string |
| http://purl.uniprot.org/citations/31864704 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2019.11.149"xsd:string |
| http://purl.uniprot.org/citations/31864704 | http://purl.uniprot.org/core/author | "Hwang J."xsd:string |
| http://purl.uniprot.org/citations/31864704 | http://purl.uniprot.org/core/author | "Kato M."xsd:string |
| http://purl.uniprot.org/citations/31864704 | http://purl.uniprot.org/core/author | "Suzuki H."xsd:string |
| http://purl.uniprot.org/citations/31864704 | http://purl.uniprot.org/core/author | "Haque M.A."xsd:string |
| http://purl.uniprot.org/citations/31864704 | http://purl.uniprot.org/core/author | "Dijke P.T."xsd:string |
| http://purl.uniprot.org/citations/31864704 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/31864704 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/31864704 | http://purl.uniprot.org/core/pages | "307-314"xsd:string |
| http://purl.uniprot.org/citations/31864704 | http://purl.uniprot.org/core/title | "THG-1 suppresses SALL4 degradation to induce stemness genes and tumorsphere formation through antagonizing NRBP1 in squamous cell carcinoma cells."xsd:string |
| http://purl.uniprot.org/citations/31864704 | http://purl.uniprot.org/core/volume | "523"xsd:string |
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