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Subject | Predicate | Object |
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http://purl.uniprot.org/citations/31867269 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/31867269 | http://www.w3.org/2000/01/rdf-schema#comment | "Objective: Endometrial cancer (EC) is the second most common gynecological cancer worldwide. Myometrial invasion (MI) is a key event in EC dissemination. This study aimed to evaluate FXYD5/dysadherin (FXYD5/Dys) expression in EC tissue and uterine aspirate (UA) biopsies and to assess molecular/functional changes associated with its expression in cellular models. Methods: FXYD5/Dys messenger RNA (mRNA) levels were determined in EC tissue and UA biopsies. FXYD5/Dys expression was evaluated in EC RNAseq data from The Cancer Genome Atlas (TCGA) and GENEVESTIGATOR tools. FXYD5/Dys impact on E-cadherin expression and cell behavior was assessed in EC Hec1a cells treated with transforming growth factor (TGF)-β1, stably transfected with ETV5, and transiently transfected with FXYD5/Dys small interfering RNA (siRNA) or pcDNA3-FXYD5/Dys plasmid. Results: FXYD5/Dys was associated with EC aggressiveness, finding high mRNA levels in tumors depicting MI > 50%, Grade 3, and intermediate/high risk of recurrence. FXYD5/Dys was highly expressed at the tumor invasive front compared to the superficial area. Most results were recapitulated in UA biopsies. FXYD5/Dys modulation in Hec1a cells altered cell migration/adhesion and E-cadherin expression. TGF-β1 treatment of Hec1a cells induced FXYD5/Dys expression. TCGA-UCEC RNAseq analysis revealed a positive correlation between FXYD5/Dys, TGF-β1, and plasminogen activator inhibitor (PAI)-1 mRNA levels. FXYD5/Dys induced nuclear factor (NF)-κB pathway activation in Hec1a cells. FXYD5/Dys mRNA levels positively correlated with transcriptional activation of NF-κB p65-regulated genes. Survival analysis revealed patient segregation into low- and high-risk groups, the latter depicting the highest FXYD5/Dys, PAI-1, tumor necrosis factor (TNF)-α, and TGF-β1 mRNA levels and shorter survival rates. Conclusion: FXYD5/Dys is a novel biomarker of EC progression related to TGF-β1 and NF-κB pathways that collectively promote tumor dissemination and result in poor patient prognosis."xsd:string |
http://purl.uniprot.org/citations/31867269 | http://purl.org/dc/terms/identifier | "doi:10.3389/fonc.2019.01306"xsd:string |
http://purl.uniprot.org/citations/31867269 | http://purl.uniprot.org/core/author | "Reventos J."xsd:string |
http://purl.uniprot.org/citations/31867269 | http://purl.uniprot.org/core/author | "Vazquez-Levin M.H."xsd:string |
http://purl.uniprot.org/citations/31867269 | http://purl.uniprot.org/core/author | "Rosso M."xsd:string |
http://purl.uniprot.org/citations/31867269 | http://purl.uniprot.org/core/author | "Orti R."xsd:string |
http://purl.uniprot.org/citations/31867269 | http://purl.uniprot.org/core/author | "Schillaci R."xsd:string |
http://purl.uniprot.org/citations/31867269 | http://purl.uniprot.org/core/author | "Colas E."xsd:string |
http://purl.uniprot.org/citations/31867269 | http://purl.uniprot.org/core/author | "Gil-Moreno A."xsd:string |
http://purl.uniprot.org/citations/31867269 | http://purl.uniprot.org/core/author | "Matos M.L."xsd:string |
http://purl.uniprot.org/citations/31867269 | http://purl.uniprot.org/core/author | "Lapyckyj L."xsd:string |
http://purl.uniprot.org/citations/31867269 | http://purl.uniprot.org/core/author | "Moiola C.P."xsd:string |
http://purl.uniprot.org/citations/31867269 | http://purl.uniprot.org/core/author | "Mercogliano M.F."xsd:string |
http://purl.uniprot.org/citations/31867269 | http://purl.uniprot.org/core/author | "Wernicke A."xsd:string |
http://purl.uniprot.org/citations/31867269 | http://purl.uniprot.org/core/author | "Besso M.J."xsd:string |
http://purl.uniprot.org/citations/31867269 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
http://purl.uniprot.org/citations/31867269 | http://purl.uniprot.org/core/name | "Front Oncol"xsd:string |
http://purl.uniprot.org/citations/31867269 | http://purl.uniprot.org/core/pages | "1306"xsd:string |
http://purl.uniprot.org/citations/31867269 | http://purl.uniprot.org/core/title | "FXYD5/Dysadherin, a Biomarker of Endometrial Cancer Myometrial Invasion and Aggressiveness: Its Relationship With TGF-beta1 and NF-kappaB Pathways."xsd:string |
http://purl.uniprot.org/citations/31867269 | http://purl.uniprot.org/core/volume | "9"xsd:string |
http://purl.uniprot.org/citations/31867269 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31867269 |
http://purl.uniprot.org/citations/31867269 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31867269 |
http://purl.uniprot.org/uniprot/#_Q04206-mappedCitation-31867269 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31867269 |
http://purl.uniprot.org/uniprot/Q04206 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/31867269 |