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http://purl.uniprot.org/citations/31870116http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/31870116http://www.w3.org/2000/01/rdf-schema#comment"

Objective

This study aimed to investigate the immunohistochemical expression of c-Myc in muscle invasive urothelial carcinoma (MIUC) of the urinary bladder and to evaluate the correlation of c-Myc expression with different clinicopathological parameters and outcome, including a relatively new histopathological tumor characteristic that is the growth pattern of tumor invasion.

Methods

A total of 66 formalin-fixed and paraffin-embedded sections of MIUC obtained from radical cystectomy specimens were enrolled. The sections were stained with c-Myc antibody using immunohistochemistry technique.

Results

Tumor cells showed variability in nuclear c-Myc expression according to the growth pattern of invasion. The median H-score of nuclear expression of infiltrative pattern was significantly higher than that of non-infiltrative pattern (p<0.001). Nuclear expression of c-Myc in tumor tissue had a significant association with poor prognostic factors (sarcomatoid variant (p<0.001), perineural invasion (p=0.037), lymphovascular invasion (p<0.001), lymph node metastasis (p<0.001), distant metastasis (p=0.042) and advanced stage grouping (p=0.001). Kaplan Meier survival analysis demonstrated that c-Myc expression could not be significantly correlated with overall survival or disease free survival rates.

Conclusion

Nuclear c-Myc seems to have a prominent role in epithelial to mesenchymal transition with consequential in tumor progression and metastasis, while it is not as much useful to predict the clinical behavior of patients with MIUC."xsd:string
http://purl.uniprot.org/citations/31870116http://purl.org/dc/terms/identifier"doi:10.31557/apjcp.2019.20.12.3735"xsd:string
http://purl.uniprot.org/citations/31870116http://purl.uniprot.org/core/author"Elsaba T.M."xsd:string
http://purl.uniprot.org/citations/31870116http://purl.uniprot.org/core/author"Nassar M.I."xsd:string
http://purl.uniprot.org/citations/31870116http://purl.uniprot.org/core/author"Abd Elzaher A.R."xsd:string
http://purl.uniprot.org/citations/31870116http://purl.uniprot.org/core/author"Elwy A.E."xsd:string
http://purl.uniprot.org/citations/31870116http://purl.uniprot.org/core/date"2019"xsd:gYear
http://purl.uniprot.org/citations/31870116http://purl.uniprot.org/core/name"Asian Pac J Cancer Prev"xsd:string
http://purl.uniprot.org/citations/31870116http://purl.uniprot.org/core/pages"3735-3746"xsd:string
http://purl.uniprot.org/citations/31870116http://purl.uniprot.org/core/title"Prognostic Value of c-Myc Immunohistochemical Expression in Muscle Invasive Urothelial Carcinoma of the Urinary Bladder: A Retrospective Study."xsd:string
http://purl.uniprot.org/citations/31870116http://purl.uniprot.org/core/volume"20"xsd:string
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