| http://purl.uniprot.org/citations/31874246 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31874246 | http://www.w3.org/2000/01/rdf-schema#comment | "Liver cancer stem cells (LCSCs) initiate hepatocellular carcinoma (HCC) and contribute to its recurrence and treatment resistance. Studies have suggested ZBP-89 as a candidate tumor suppressor in HCC. We explored the role of ZBP-89 in the regulation of LCSCs. This study was performed in liver tissue samples from 104 HCC patients, 2 cell lines and mouse tumor models. We demonstrated that ZBP-89 was weakly expressed in LCSCs. Patients with high expression of LCSC markers displayed reduced survivals and higher recurrence rates after curative surgical operation. The expression of ZBP-89 was predictive for decreased recurrence. LCSC markers were negatively correlated with ZBP-89 in HCC tissues and in enriched liver tumor spheres. The exogenous expression of ZBP-89 attenuated the tumor-sphere formation and secondary colony formation capabilities of LCSCs in vitro and tumorigenicity in vivo. Furthermore, the negative effect of ZBP-89 on cancer stemness was Notch1-dependent. Localized with Notch1 intracellular domain (NICD1) in the nucleus, ZBP-89 repressed the Notch1 signaling pathway by competitive binding to NICD1 with MAML1. Collectively, ZBP-89 negatively regulates HCC stemness via inhibiting the Notch1 signaling."xsd:string |
| http://purl.uniprot.org/citations/31874246 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.canlet.2019.12.026"xsd:string |
| http://purl.uniprot.org/citations/31874246 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/31874246 | http://purl.uniprot.org/core/author | "Ren J."xsd:string |
| http://purl.uniprot.org/citations/31874246 | http://purl.uniprot.org/core/author | "Wang S."xsd:string |
| http://purl.uniprot.org/citations/31874246 | http://purl.uniprot.org/core/author | "Yu J."xsd:string |
| http://purl.uniprot.org/citations/31874246 | http://purl.uniprot.org/core/author | "Yang S."xsd:string |
| http://purl.uniprot.org/citations/31874246 | http://purl.uniprot.org/core/author | "Zheng Z."xsd:string |
| http://purl.uniprot.org/citations/31874246 | http://purl.uniprot.org/core/author | "Wang N."xsd:string |
| http://purl.uniprot.org/citations/31874246 | http://purl.uniprot.org/core/author | "Yang S.L."xsd:string |
| http://purl.uniprot.org/citations/31874246 | http://purl.uniprot.org/core/author | "Li M.Y."xsd:string |
| http://purl.uniprot.org/citations/31874246 | http://purl.uniprot.org/core/author | "Lai P.B."xsd:string |
| http://purl.uniprot.org/citations/31874246 | http://purl.uniprot.org/core/author | "Chen G.G."xsd:string |
| http://purl.uniprot.org/citations/31874246 | http://purl.uniprot.org/core/author | "Merchant J.L."xsd:string |
| http://purl.uniprot.org/citations/31874246 | http://purl.uniprot.org/core/author | "Liu L.P."xsd:string |
| http://purl.uniprot.org/citations/31874246 | http://purl.uniprot.org/core/author | "Chong C.C."xsd:string |
| http://purl.uniprot.org/citations/31874246 | http://purl.uniprot.org/core/author | "Hu B.G."xsd:string |
| http://purl.uniprot.org/citations/31874246 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/31874246 | http://purl.uniprot.org/core/name | "Cancer Lett"xsd:string |
| http://purl.uniprot.org/citations/31874246 | http://purl.uniprot.org/core/pages | "70-80"xsd:string |
| http://purl.uniprot.org/citations/31874246 | http://purl.uniprot.org/core/title | "ZBP-89 negatively regulates self-renewal of liver cancer stem cells via suppression of Notch1 signaling pathway."xsd:string |
| http://purl.uniprot.org/citations/31874246 | http://purl.uniprot.org/core/volume | "472"xsd:string |
| http://purl.uniprot.org/citations/31874246 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31874246 |
| http://purl.uniprot.org/citations/31874246 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31874246 |