| http://purl.uniprot.org/citations/31875546 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31875546 | http://www.w3.org/2000/01/rdf-schema#comment | "Intramuscular motor innervation is an essential process in neuromuscular development. Recently, mutations in COL25A1, encoding CLAC-P/collagen XXV, have been linked to the development of a congenital cranial dysinnervation disorder (CCDD). Yet the molecular mechanisms of intramuscular innervation and the etiology of CCDD related to COL25A1 have remained elusive. Here, we report that muscle-derived collagen XXV is indispensable for intramuscular innervation. In developing skeletal muscles, Col25a1 expression is tightly regulated by muscle excitation. In vitro and cell-based assays reveal a direct interaction between collagen XXV and receptor protein tyrosine phosphatases (PTPs) σ and δ. Motor explant assays show that expression of collagen XXV in target cells attracts motor axons, but this is inhibited by exogenous PTPσ/δ. CCDD mutations attenuate motor axon attraction by reducing collagen XXV-PTPσ/δ interaction. Overall, our study identifies PTPσ/δ as putative receptors for collagen XXV, implicating collagen XXV and PTPσ/δ in intramuscular innervation and a developmental ocular motor disorder."xsd:string |
| http://purl.uniprot.org/citations/31875546 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2019.11.112"xsd:string |
| http://purl.uniprot.org/citations/31875546 | http://purl.uniprot.org/core/author | "Hashimoto T."xsd:string |
| http://purl.uniprot.org/citations/31875546 | http://purl.uniprot.org/core/author | "Sato T."xsd:string |
| http://purl.uniprot.org/citations/31875546 | http://purl.uniprot.org/core/author | "Yoshida T."xsd:string |
| http://purl.uniprot.org/citations/31875546 | http://purl.uniprot.org/core/author | "Eguchi T."xsd:string |
| http://purl.uniprot.org/citations/31875546 | http://purl.uniprot.org/core/author | "Nishio S."xsd:string |
| http://purl.uniprot.org/citations/31875546 | http://purl.uniprot.org/core/author | "Yamanashi Y."xsd:string |
| http://purl.uniprot.org/citations/31875546 | http://purl.uniprot.org/core/author | "Iwatsubo T."xsd:string |
| http://purl.uniprot.org/citations/31875546 | http://purl.uniprot.org/core/author | "Harada A."xsd:string |
| http://purl.uniprot.org/citations/31875546 | http://purl.uniprot.org/core/author | "Hirasawa T."xsd:string |
| http://purl.uniprot.org/citations/31875546 | http://purl.uniprot.org/core/author | "Wakabayashi T."xsd:string |
| http://purl.uniprot.org/citations/31875546 | http://purl.uniprot.org/core/author | "Oizumi H."xsd:string |
| http://purl.uniprot.org/citations/31875546 | http://purl.uniprot.org/core/author | "Munezane H."xsd:string |
| http://purl.uniprot.org/citations/31875546 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31875546 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/31875546 | http://purl.uniprot.org/core/pages | "4362-4376.e6"xsd:string |
| http://purl.uniprot.org/citations/31875546 | http://purl.uniprot.org/core/title | "Roles of Collagen XXV and Its Putative Receptors PTPsigma/delta in Intramuscular Motor Innervation and Congenital Cranial Dysinnervation Disorder."xsd:string |
| http://purl.uniprot.org/citations/31875546 | http://purl.uniprot.org/core/volume | "29"xsd:string |
| http://purl.uniprot.org/citations/31875546 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31875546 |
| http://purl.uniprot.org/citations/31875546 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31875546 |
| http://purl.uniprot.org/uniprot/#_D3Z7B8-mappedCitation-31875546 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31875546 |
| http://purl.uniprot.org/uniprot/#_D3Z7B9-mappedCitation-31875546 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31875546 |
| http://purl.uniprot.org/uniprot/#_A0A087WNT5-mappedCitation-31875546 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31875546 |