| http://purl.uniprot.org/citations/31877058 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31877058 | http://www.w3.org/2000/01/rdf-schema#comment | "Excess of Aβ42 peptide is considered a hallmark of the disease. Here we express the human Aβ42 peptide to assay the neuroprotective effects of PI3K in adult Drosophila melanogaster. The neuronal expression of the human peptide elicits progressive toxicity in the adult fly. The pathological traits include reduced axonal transport, synapse loss, defective climbing ability and olfactory perception, as well as lifespan reduction. The Aβ42-dependent synapse decay does not involve transcriptional changes in the core synaptic protein encoding genes bruchpilot, liprin and synaptobrevin. All toxicity features, however, are suppressed by the coexpression of PI3K. Moreover, PI3K activation induces a significant increase of 6E10 and thioflavin-positive amyloid deposits. Mechanistically, we suggest that Aβ42-Ser26 could be a candidate residue for direct or indirect phosphorylation by PI3K. Along with these in vivo experiments, we further analyze Aβ42 toxicity and its suppression by PI3K activation in in vitro assays with SH-SY5Y human neuroblastoma cell cultures, where Aβ42 aggregation into large insoluble deposits is reproduced. Finally, we show that the Aβ42 toxicity syndrome includes the transcriptional shut down of PI3K expression. Taken together, these results uncover a potential novel pharmacological strategy against this disease through the restoration of PI3K activity."xsd:string |
| http://purl.uniprot.org/citations/31877058 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e19-05-0303"xsd:string |
| http://purl.uniprot.org/citations/31877058 | http://purl.uniprot.org/core/author | "Ferrus A."xsd:string |
| http://purl.uniprot.org/citations/31877058 | http://purl.uniprot.org/core/author | "Romero N."xsd:string |
| http://purl.uniprot.org/citations/31877058 | http://purl.uniprot.org/core/author | "Casas-Tinto S."xsd:string |
| http://purl.uniprot.org/citations/31877058 | http://purl.uniprot.org/core/author | "Acebes A."xsd:string |
| http://purl.uniprot.org/citations/31877058 | http://purl.uniprot.org/core/author | "Arnes M."xsd:string |
| http://purl.uniprot.org/citations/31877058 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/31877058 | http://purl.uniprot.org/core/name | "Mol Biol Cell"xsd:string |
| http://purl.uniprot.org/citations/31877058 | http://purl.uniprot.org/core/pages | "244-260"xsd:string |
| http://purl.uniprot.org/citations/31877058 | http://purl.uniprot.org/core/title | "PI3K activation prevents Abeta42-induced synapse loss and favors insoluble amyloid deposit formation."xsd:string |
| http://purl.uniprot.org/citations/31877058 | http://purl.uniprot.org/core/volume | "31"xsd:string |
| http://purl.uniprot.org/citations/31877058 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31877058 |
| http://purl.uniprot.org/citations/31877058 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31877058 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KF38-mappedCitation-31877058 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31877058 |
| http://purl.uniprot.org/uniprot/#_A0A0B4K6V0-mappedCitation-31877058 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31877058 |
| http://purl.uniprot.org/uniprot/#_E1JHD6-mappedCitation-31877058 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31877058 |
| http://purl.uniprot.org/uniprot/#_A0A0B4K7V8-mappedCitation-31877058 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31877058 |
| http://purl.uniprot.org/uniprot/#_A0A0B4K843-mappedCitation-31877058 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31877058 |
| http://purl.uniprot.org/uniprot/#_A0A0B4LIA3-mappedCitation-31877058 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31877058 |
| http://purl.uniprot.org/uniprot/#_A0A0B4K7K9-mappedCitation-31877058 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31877058 |
| http://purl.uniprot.org/uniprot/#_A0A0B4LG34-mappedCitation-31877058 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31877058 |
| http://purl.uniprot.org/uniprot/#_A8DY79-mappedCitation-31877058 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31877058 |
| http://purl.uniprot.org/uniprot/#_A8DYM0-mappedCitation-31877058 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31877058 |