| http://purl.uniprot.org/citations/31879337 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31879337 | http://www.w3.org/2000/01/rdf-schema#comment | "Lipid droplets (LDs) are dynamic organelles that store neutral lipids during times of energy excess, such as after a meal. LDs serve as an energy reservoir during fasting and have a buffering capacity that prevents lipotoxicity. Autophagy and the autophagic machinery have been proposed to play a role in LD biogenesis, but the underlying molecular mechanism remains unclear. Here, we show that when nuclear receptor co-repressor 1 (NCoR1), which inhibits the transactivation of nuclear receptors, accumulates because of autophagy suppression, LDs decrease in size and number. Ablation of ATG7, a gene essential for autophagy, suppressed the expression of gene targets of liver X receptor α, a nuclear receptor responsible for fatty acid and triglyceride synthesis in an NCoR1-dependent manner. LD accumulation in response to fasting and after hepatectomy was hampered by the suppression of autophagy. These results suggest that autophagy controls physiological hepatosteatosis by fine-tuning NCoR1 protein levels."xsd:string |
| http://purl.uniprot.org/citations/31879337 | http://purl.org/dc/terms/identifier | "doi:10.26508/lsa.201900513"xsd:string |
| http://purl.uniprot.org/citations/31879337 | http://purl.uniprot.org/core/author | "Koike M."xsd:string |
| http://purl.uniprot.org/citations/31879337 | http://purl.uniprot.org/core/author | "Saito T."xsd:string |
| http://purl.uniprot.org/citations/31879337 | http://purl.uniprot.org/core/author | "Kuma A."xsd:string |
| http://purl.uniprot.org/citations/31879337 | http://purl.uniprot.org/core/author | "Mizushima N."xsd:string |
| http://purl.uniprot.org/citations/31879337 | http://purl.uniprot.org/core/author | "Yabe T."xsd:string |
| http://purl.uniprot.org/citations/31879337 | http://purl.uniprot.org/core/author | "Lee H.C."xsd:string |
| http://purl.uniprot.org/citations/31879337 | http://purl.uniprot.org/core/author | "Sugiura Y."xsd:string |
| http://purl.uniprot.org/citations/31879337 | http://purl.uniprot.org/core/author | "Komatsu M."xsd:string |
| http://purl.uniprot.org/citations/31879337 | http://purl.uniprot.org/core/author | "Suematsu M."xsd:string |
| http://purl.uniprot.org/citations/31879337 | http://purl.uniprot.org/core/author | "Sou Y.S."xsd:string |
| http://purl.uniprot.org/citations/31879337 | http://purl.uniprot.org/core/author | "Waguri S."xsd:string |
| http://purl.uniprot.org/citations/31879337 | http://purl.uniprot.org/core/author | "Terai S."xsd:string |
| http://purl.uniprot.org/citations/31879337 | http://purl.uniprot.org/core/author | "Yokomizo T."xsd:string |
| http://purl.uniprot.org/citations/31879337 | http://purl.uniprot.org/core/author | "Takahashi S.S."xsd:string |
| http://purl.uniprot.org/citations/31879337 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/31879337 | http://purl.uniprot.org/core/name | "Life Sci Alliance"xsd:string |
| http://purl.uniprot.org/citations/31879337 | http://purl.uniprot.org/core/pages | "e201900513"xsd:string |
| http://purl.uniprot.org/citations/31879337 | http://purl.uniprot.org/core/title | "Loss of autophagy impairs physiological steatosis by accumulation of NCoR1."xsd:string |
| http://purl.uniprot.org/citations/31879337 | http://purl.uniprot.org/core/volume | "3"xsd:string |
| http://purl.uniprot.org/citations/31879337 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31879337 |
| http://purl.uniprot.org/citations/31879337 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31879337 |
| http://purl.uniprot.org/uniprot/#_A0A0A0MQN4-mappedCitation-31879337 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31879337 |