| http://purl.uniprot.org/citations/31894362 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31894362 | http://www.w3.org/2000/01/rdf-schema#comment | "The chemotherapeutic drug epirubicin increases the exosomal export of miR-503 in endothelial cells. To understand the mechanisms behind this process, we transfected endothelial cells with miR-503 carrying a biotin tag. Then, we pulled-down the proteins interacting with miR-503 and studied their role in microRNA exosomal export. A total of four different binding partners were identified by mass spectrometry and validated by western blotting and negative controls, among them ANXA2 and hnRNPA2B1. Using knock-down systems combined with pull-down analysis, we determined that epirubicin mediates the export of miR-503 by disrupting the interaction between hnRNPA2B1 and miR-503. Then, both ANXA2 and miR-503 are sorted into exosomes while hnRNPA2B1 is relocated into the nucleus. The combination of these processes culminates in the increased export of miR-503. These results suggest, for the first time, that RNA-binding proteins can negatively regulate the exosomal sorting of microRNAs."xsd:string |
| http://purl.uniprot.org/citations/31894362 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00018-019-03425-6"xsd:string |
| http://purl.uniprot.org/citations/31894362 | http://purl.uniprot.org/core/author | "Dequiedt F."xsd:string |
| http://purl.uniprot.org/citations/31894362 | http://purl.uniprot.org/core/author | "Lion M."xsd:string |
| http://purl.uniprot.org/citations/31894362 | http://purl.uniprot.org/core/author | "Struman I."xsd:string |
| http://purl.uniprot.org/citations/31894362 | http://purl.uniprot.org/core/author | "Boeckx A."xsd:string |
| http://purl.uniprot.org/citations/31894362 | http://purl.uniprot.org/core/author | "Perez-Boza J."xsd:string |
| http://purl.uniprot.org/citations/31894362 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/31894362 | http://purl.uniprot.org/core/name | "Cell Mol Life Sci"xsd:string |
| http://purl.uniprot.org/citations/31894362 | http://purl.uniprot.org/core/pages | "4413-4428"xsd:string |
| http://purl.uniprot.org/citations/31894362 | http://purl.uniprot.org/core/title | "hnRNPA2B1 inhibits the exosomal export of miR-503 in endothelial cells."xsd:string |
| http://purl.uniprot.org/citations/31894362 | http://purl.uniprot.org/core/volume | "77"xsd:string |
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