| http://purl.uniprot.org/citations/31901148 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31901148 | http://www.w3.org/2000/01/rdf-schema#comment | "Malignant tumors, including colorectal cancer (CRC), usually rely on ATP generation through aerobic glycolysis for both rapid growth and chemotherapy resistance. The M2 isoform of pyruvate kinase (PKM2) has a key role in catalyzing glycolysis, and PKM2 expression varies even within a single tumor. In this study, we confirmed that expression of PKM2 is heterogeneous in CRC cells, namely high in oxaliplatin-resistant cells but relatively low in sensitive cells, and found that chemoresistant cells had enhanced glycolysis and ATP production. In addition, we report a PKM2-dependent mechanism through which chemosensitive cells may gradually transform into chemoresistant cells. The circular RNA hsa_circ_0005963 (termed ciRS-122 in this study), which was determined to be a sponge for the PKM2-targeting miR-122, was positively correlated with chemoresistance. In vitro and in vivo studies showed that exosomes from oxaliplatin-resistant cells delivered ciRS-122 to sensitive cells, thereby promoting glycolysis and drug resistance through miR-122 sponging and PKM2 upregulation. Moreover, si-ciRS-122 transported by exosomes could suppress glycolysis and reverse resistance to oxaliplatin by regulating the ciRS-122-miR-122-PKM2 pathway in vivo. Exosomes derived from chemoresistant CRC cells could transfer ciRS-122 across cells and promote glycolysis to reduce drug susceptibility in chemosensitive cells. This intercellular signal delivery suggests a potential novel therapeutic target and establishes a foundation for future clinical applications in drug-resistant CRC."xsd:string |
| http://purl.uniprot.org/citations/31901148 | http://purl.org/dc/terms/identifier | "doi:10.1002/1878-0261.12629"xsd:string |
| http://purl.uniprot.org/citations/31901148 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/31901148 | http://purl.uniprot.org/core/author | "Liu R."xsd:string |
| http://purl.uniprot.org/citations/31901148 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
| http://purl.uniprot.org/citations/31901148 | http://purl.uniprot.org/core/author | "Wang X."xsd:string |
| http://purl.uniprot.org/citations/31901148 | http://purl.uniprot.org/core/author | "Yang H."xsd:string |
| http://purl.uniprot.org/citations/31901148 | http://purl.uniprot.org/core/author | "Zhu K."xsd:string |
| http://purl.uniprot.org/citations/31901148 | http://purl.uniprot.org/core/author | "Ying G."xsd:string |
| http://purl.uniprot.org/citations/31901148 | http://purl.uniprot.org/core/author | "Zhan Y."xsd:string |
| http://purl.uniprot.org/citations/31901148 | http://purl.uniprot.org/core/author | "Bai M."xsd:string |
| http://purl.uniprot.org/citations/31901148 | http://purl.uniprot.org/core/author | "Fan Q."xsd:string |
| http://purl.uniprot.org/citations/31901148 | http://purl.uniprot.org/core/author | "Deng T."xsd:string |
| http://purl.uniprot.org/citations/31901148 | http://purl.uniprot.org/core/author | "Ning T."xsd:string |
| http://purl.uniprot.org/citations/31901148 | http://purl.uniprot.org/core/author | "Ba Y."xsd:string |
| http://purl.uniprot.org/citations/31901148 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/31901148 | http://purl.uniprot.org/core/name | "Mol Oncol"xsd:string |
| http://purl.uniprot.org/citations/31901148 | http://purl.uniprot.org/core/pages | "539-555"xsd:string |
| http://purl.uniprot.org/citations/31901148 | http://purl.uniprot.org/core/title | "Exosome-delivered circRNA promotes glycolysis to induce chemoresistance through the miR-122-PKM2 axis in colorectal cancer."xsd:string |
| http://purl.uniprot.org/citations/31901148 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/31901148 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31901148 |
| http://purl.uniprot.org/citations/31901148 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31901148 |
| http://purl.uniprot.org/uniprot/#_A0A804F6T5-mappedCitation-31901148 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31901148 |
| http://purl.uniprot.org/uniprot/#_A0A804F729-mappedCitation-31901148 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31901148 |