| http://purl.uniprot.org/citations/31901447 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31901447 | http://www.w3.org/2000/01/rdf-schema#comment | "Lipid droplets (LDs) provide a reservoir for triacylglycerol storage and are a central hub for fatty acid trafficking and signaling in cells. Lipolysis promotes mitochondrial biogenesis and oxidative metabolism via a SIRT1/PGC-1α/PPARα-dependent pathway through an unknown mechanism. Herein, we identify that monounsaturated fatty acids (MUFAs) allosterically activate SIRT1 toward select peptide-substrates such as PGC-1α. MUFAs enhance PGC-1α/PPARα signaling and promote oxidative metabolism in cells and animal models in a SIRT1-dependent manner. Moreover, we characterize the LD protein perilipin 5 (PLIN5), which is known to enhance mitochondrial biogenesis and function, to be a fatty-acid-binding protein that preferentially binds LD-derived monounsaturated fatty acids and traffics them to the nucleus following cAMP/PKA-mediated lipolytic stimulation. Thus, these studies identify the first-known endogenous allosteric modulators of SIRT1 and characterize a LD-nuclear signaling axis that underlies the known metabolic benefits of MUFAs and PLIN5."xsd:string |
| http://purl.uniprot.org/citations/31901447 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2019.12.003"xsd:string |
| http://purl.uniprot.org/citations/31901447 | http://purl.uniprot.org/core/author | "Perez M."xsd:string |
| http://purl.uniprot.org/citations/31901447 | http://purl.uniprot.org/core/author | "Khan S.A."xsd:string |
| http://purl.uniprot.org/citations/31901447 | http://purl.uniprot.org/core/author | "Graham M.J."xsd:string |
| http://purl.uniprot.org/citations/31901447 | http://purl.uniprot.org/core/author | "Witthuhn B.A."xsd:string |
| http://purl.uniprot.org/citations/31901447 | http://purl.uniprot.org/core/author | "Mashek D.G."xsd:string |
| http://purl.uniprot.org/citations/31901447 | http://purl.uniprot.org/core/author | "Mashek M.T."xsd:string |
| http://purl.uniprot.org/citations/31901447 | http://purl.uniprot.org/core/author | "Parker L."xsd:string |
| http://purl.uniprot.org/citations/31901447 | http://purl.uniprot.org/core/author | "Bernlohr D.A."xsd:string |
| http://purl.uniprot.org/citations/31901447 | http://purl.uniprot.org/core/author | "Chow L.S."xsd:string |
| http://purl.uniprot.org/citations/31901447 | http://purl.uniprot.org/core/author | "Mead L.E."xsd:string |
| http://purl.uniprot.org/citations/31901447 | http://purl.uniprot.org/core/author | "Karanja K.K."xsd:string |
| http://purl.uniprot.org/citations/31901447 | http://purl.uniprot.org/core/author | "Heden T.D."xsd:string |
| http://purl.uniprot.org/citations/31901447 | http://purl.uniprot.org/core/author | "Najt C.P."xsd:string |
| http://purl.uniprot.org/citations/31901447 | http://purl.uniprot.org/core/author | "Franklin M.P."xsd:string |
| http://purl.uniprot.org/citations/31901447 | http://purl.uniprot.org/core/author | "Heier J.L."xsd:string |
| http://purl.uniprot.org/citations/31901447 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/31901447 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/31901447 | http://purl.uniprot.org/core/pages | "810-824.e8"xsd:string |
| http://purl.uniprot.org/citations/31901447 | http://purl.uniprot.org/core/title | "Lipid Droplet-Derived Monounsaturated Fatty Acids Traffic via PLIN5 to Allosterically Activate SIRT1."xsd:string |
| http://purl.uniprot.org/citations/31901447 | http://purl.uniprot.org/core/volume | "77"xsd:string |
| http://purl.uniprot.org/citations/31901447 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31901447 |
| http://purl.uniprot.org/citations/31901447 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31901447 |