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http://purl.uniprot.org/citations/31901866http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/31901866http://www.w3.org/2000/01/rdf-schema#comment"

Background

Heterogeneous nuclear ribonucleoprotein (hnRNP) A2/B1 is an important RNA-binding protein that affects the RNA processing, splicing, transport and stability of many genes. hnRNPA2/B1 is expressed during proliferation and metastasis of various cancer types and promotes such processes. However, the precise role and mechanism of hnRNPA2/B1 in breast cancer remain unclear.

Methods

The association of hnRNPA2/B1 with breast cancer metastasis was assessed using tissue chips, mouse models and publicly available data. The role and mechanism of hnRNPA2/B1 in breast cancer metastasis were studied in cell lines and mouse models.

Findings

In contrast to other cancer research findings, hnRNPA2/B1 expression was negatively correlated with breast cancer metastasis. hnRNPA2/B1 inhibited MDA-MB-231 triple-negative breast cancer (TNBC) cell metastasis in vitro and in vivo. hnRNPA2/B1 knockout activated ERK-MAPK/Twist and GR-beta/TCF4 pathways but inhibited STAT3 and WNT/TCF4 signalling pathways. Profilin 2 (PFN2) promoted breast cancer cell migration and invasion, whereas hnRNPA2/B1 bound directly to the UAGGG locus in the 3'-untranslated region of PFN2 mRNA and reduced the stability of PFN2 mRNA.

Interpretation

Our data supported the role of hnRNPA2/B1 in tumour metastasis risk and survival prediction in patients with breast cancer. The inhibitory role of hnRNPA2/B1 in metastasis was a balance of downstream multiple genes and signalling pathways. PFN2 downregulation by hnRNPA2/B1 might partly explain the inhibitory mechanism of hnRNPA2/B1 in breast cancer metastasis. Therefore, hnRNPA2/B1 might be used as a new prognostic biomarker and valuable molecular target for breast cancer treatments."xsd:string
http://purl.uniprot.org/citations/31901866http://purl.org/dc/terms/identifier"doi:10.1016/j.ebiom.2019.11.044"xsd:string
http://purl.uniprot.org/citations/31901866http://purl.uniprot.org/core/author"Chen C."xsd:string
http://purl.uniprot.org/citations/31901866http://purl.uniprot.org/core/author"Li H."xsd:string
http://purl.uniprot.org/citations/31901866http://purl.uniprot.org/core/author"Liu Y."xsd:string
http://purl.uniprot.org/citations/31901866http://purl.uniprot.org/core/author"Li S."xsd:string
http://purl.uniprot.org/citations/31901866http://purl.uniprot.org/core/author"Liu F."xsd:string
http://purl.uniprot.org/citations/31901866http://purl.uniprot.org/core/author"Li X."xsd:string
http://purl.uniprot.org/citations/31901866http://purl.uniprot.org/core/author"Yang L."xsd:string
http://purl.uniprot.org/citations/31901866http://purl.uniprot.org/core/author"Ding X."xsd:string
http://purl.uniprot.org/citations/31901866http://purl.uniprot.org/core/author"Lu K."xsd:string
http://purl.uniprot.org/citations/31901866http://purl.uniprot.org/core/author"Han R."xsd:string
http://purl.uniprot.org/citations/31901866http://purl.uniprot.org/core/author"Chen B.B."xsd:string
http://purl.uniprot.org/citations/31901866http://purl.uniprot.org/core/author"Deng X.L."xsd:string
http://purl.uniprot.org/citations/31901866http://purl.uniprot.org/core/author"Xu D.H."xsd:string
http://purl.uniprot.org/citations/31901866http://purl.uniprot.org/core/author"Shi S.L."xsd:string
http://purl.uniprot.org/citations/31901866http://purl.uniprot.org/core/author"Tian H.M."xsd:string
http://purl.uniprot.org/citations/31901866http://purl.uniprot.org/core/author"Gao L.B."xsd:string
http://purl.uniprot.org/citations/31901866http://purl.uniprot.org/core/date"2020"xsd:gYear
http://purl.uniprot.org/citations/31901866http://purl.uniprot.org/core/name"EBioMedicine"xsd:string
http://purl.uniprot.org/citations/31901866http://purl.uniprot.org/core/pages"102583"xsd:string
http://purl.uniprot.org/citations/31901866http://purl.uniprot.org/core/title"Heterogeneous nuclear ribonucleoprotein A2/B1 is a negative regulator of human breast cancer metastasis by maintaining the balance of multiple genes and pathways."xsd:string
http://purl.uniprot.org/citations/31901866http://purl.uniprot.org/core/volume"51"xsd:string
http://purl.uniprot.org/citations/31901866http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/31901866
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