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| http://purl.uniprot.org/citations/31904398 | http://www.w3.org/2000/01/rdf-schema#comment | "RLIP (Ral-interacting protein) is a multifunctional protein that couples ATP hydrolysis with the movement of substances. Its primary function appears to be in the plasma membrane, where it catalyzes the ATP-dependent efflux of glutathione-conjugates (GS-Es), as well as un-metabolized drugs and toxins. In the plasma membrane, its interaction with the clathrin adaptor protein AP2 localizes it to endocytic vesicle, where its GS-E-stimulated ATPase and transport activity are required for clathrin-dependent endocytosis (CDE). CDE is an essential mechanism for internalizing ligand-receptor complexes that signal proliferation (EGF, insulin, IGF1), apoptosis (TNFα, TRAIL, Fas-L), and differentiation and morphogenesis (TGFβ, WNT, Notch, SHH). Aberrant functioning of these pathways appears crucial for most cancer cells to evade apoptosis, invade surrounding tissues, and metastasize. Internalization of receptor-ligand complexes by CDE begins a sequence of events that can terminate, initiate, or modulate downstream signaling; the consequences of signaling through these downstream pathways may be inherently different in cancer and normal cells, a view supported by numerous basic and clinical observations. In this review, we will discuss the GS-E transport activity of RLIP, which determines the rate of ligand endocytosis, and how the inhibition and/or depletion of RLIP globally disrupts in ligand-receptor signaling."xsd:string |
| http://purl.uniprot.org/citations/31904398 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbcan.2020.188337"xsd:string |
| http://purl.uniprot.org/citations/31904398 | http://purl.uniprot.org/core/author | "Verma N."xsd:string |
| http://purl.uniprot.org/citations/31904398 | http://purl.uniprot.org/core/author | "Awasthi S."xsd:string |
| http://purl.uniprot.org/citations/31904398 | http://purl.uniprot.org/core/author | "Horne D."xsd:string |
| http://purl.uniprot.org/citations/31904398 | http://purl.uniprot.org/core/author | "Salgia R."xsd:string |
| http://purl.uniprot.org/citations/31904398 | http://purl.uniprot.org/core/author | "Singhal S.S."xsd:string |
| http://purl.uniprot.org/citations/31904398 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/31904398 | http://purl.uniprot.org/core/name | "Biochim Biophys Acta Rev Cancer"xsd:string |
| http://purl.uniprot.org/citations/31904398 | http://purl.uniprot.org/core/pages | "188337"xsd:string |
| http://purl.uniprot.org/citations/31904398 | http://purl.uniprot.org/core/title | "RLIP controls receptor-ligand signaling by regulating clathrin-dependent endocytosis."xsd:string |
| http://purl.uniprot.org/citations/31904398 | http://purl.uniprot.org/core/volume | "1873"xsd:string |
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