| http://purl.uniprot.org/citations/31907454 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31907454 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31907454 | http://www.w3.org/2000/01/rdf-schema#comment | "The human integral membrane protein SERINC5 potently restricts HIV-1 infectivity and sensitizes the virus to antibody-mediated neutralization. Here, using cryo-EM, we determine the structures of human SERINC5 and its orthologue from Drosophila melanogaster at subnanometer and near-atomic resolution, respectively. The structures reveal a novel fold comprised of ten transmembrane helices organized into two subdomains and bisected by a long diagonal helix. A lipid binding groove and clusters of conserved residues highlight potential functional sites. A structure-based mutagenesis scan identified surface-exposed regions and the interface between the subdomains of SERINC5 as critical for HIV-1-restriction activity. The same regions are also important for viral sensitization to neutralizing antibodies, directly linking the antiviral activity of SERINC5 with remodeling of the HIV-1 envelope glycoprotein."xsd:string |
| http://purl.uniprot.org/citations/31907454 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41594-019-0357-0"xsd:string |
| http://purl.uniprot.org/citations/31907454 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41594-019-0357-0"xsd:string |
| http://purl.uniprot.org/citations/31907454 | http://purl.uniprot.org/core/author | "Maslen S.L."xsd:string |
| http://purl.uniprot.org/citations/31907454 | http://purl.uniprot.org/core/author | "Maslen S.L."xsd:string |
| http://purl.uniprot.org/citations/31907454 | http://purl.uniprot.org/core/author | "Robinson C.V."xsd:string |
| http://purl.uniprot.org/citations/31907454 | http://purl.uniprot.org/core/author | "Robinson C.V."xsd:string |
| http://purl.uniprot.org/citations/31907454 | http://purl.uniprot.org/core/author | "Takeuchi Y."xsd:string |
| http://purl.uniprot.org/citations/31907454 | http://purl.uniprot.org/core/author | "Takeuchi Y."xsd:string |
| http://purl.uniprot.org/citations/31907454 | http://purl.uniprot.org/core/author | "Pye V.E."xsd:string |
| http://purl.uniprot.org/citations/31907454 | http://purl.uniprot.org/core/author | "Pye V.E."xsd:string |
| http://purl.uniprot.org/citations/31907454 | http://purl.uniprot.org/core/author | "Stansfeld P.J."xsd:string |
| http://purl.uniprot.org/citations/31907454 | http://purl.uniprot.org/core/author | "Stansfeld P.J."xsd:string |
| http://purl.uniprot.org/citations/31907454 | http://purl.uniprot.org/core/author | "Struwe W.B."xsd:string |
| http://purl.uniprot.org/citations/31907454 | http://purl.uniprot.org/core/author | "Struwe W.B."xsd:string |
| http://purl.uniprot.org/citations/31907454 | http://purl.uniprot.org/core/author | "Skehel J.M."xsd:string |
| http://purl.uniprot.org/citations/31907454 | http://purl.uniprot.org/core/author | "Skehel J.M."xsd:string |
| http://purl.uniprot.org/citations/31907454 | http://purl.uniprot.org/core/author | "Bertelli C."xsd:string |
| http://purl.uniprot.org/citations/31907454 | http://purl.uniprot.org/core/author | "Bertelli C."xsd:string |
| http://purl.uniprot.org/citations/31907454 | http://purl.uniprot.org/core/author | "Pizzato M."xsd:string |
| http://purl.uniprot.org/citations/31907454 | http://purl.uniprot.org/core/author | "Pizzato M."xsd:string |
| http://purl.uniprot.org/citations/31907454 | http://purl.uniprot.org/core/author | "Rosa A."xsd:string |
| http://purl.uniprot.org/citations/31907454 | http://purl.uniprot.org/core/author | "Rosa A."xsd:string |