| http://purl.uniprot.org/citations/31907535 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31907535 | http://www.w3.org/2000/01/rdf-schema#comment | "Angiogenesis in the developing cerebral cortex accompanies cortical neurogenesis. However, the precise mechanisms underlying cortical angiogenesis at the embryonic stage remain largely unknown. Here, we show that radial glia-derived vascular cell adhesion molecule 1 (VCAM1) coordinates cortical vascularization through different enrichments in the proximal and distal radial glial processes. We found that VCAM1 was highly enriched around the blood vessels in the inner ventricular zone (VZ), preventing the ingrowth of blood vessels into the mitotic cell layer along the ventricular surface. Disrupting the enrichment of VCAM1 surrounding the blood vessels by a tetraspanin-blocking peptide or conditional deletion of Vcam1 gene in neural progenitor cells increased angiogenesis in the inner VZ. Conversely, VCAM1 expressed in the basal endfeet of radial glial processes promoted angiogenic sprouting from the perineural vascular plexus (PNVP). In utero, overexpression of VCAM1 increased the vessel density in the cortical plate, while knockdown of Vcam1 accomplished the opposite. In vitro, we observed that VCAM1 bidirectionally affected endothelial cell proliferation in a concentration-dependent manner. Taken together, our findings identify that distinct concentrations of VCAM1 around VZ blood vessels and the PNVP differently organize cortical angiogenesis during late embryogenesis."xsd:string |
| http://purl.uniprot.org/citations/31907535 | http://purl.org/dc/terms/identifier | "doi:10.1093/cercor/bhz337"xsd:string |
| http://purl.uniprot.org/citations/31907535 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/31907535 | http://purl.uniprot.org/core/author | "Shen Q."xsd:string |
| http://purl.uniprot.org/citations/31907535 | http://purl.uniprot.org/core/author | "Zhang S."xsd:string |
| http://purl.uniprot.org/citations/31907535 | http://purl.uniprot.org/core/author | "Wang H.J."xsd:string |
| http://purl.uniprot.org/citations/31907535 | http://purl.uniprot.org/core/author | "Hu X.L."xsd:string |
| http://purl.uniprot.org/citations/31907535 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/31907535 | http://purl.uniprot.org/core/name | "Cereb Cortex"xsd:string |
| http://purl.uniprot.org/citations/31907535 | http://purl.uniprot.org/core/pages | "3717-3730"xsd:string |
| http://purl.uniprot.org/citations/31907535 | http://purl.uniprot.org/core/title | "Radial Glial Cell-Derived VCAM1 Regulates Cortical Angiogenesis Through Distinct Enrichments in the Proximal and Distal Radial Processes."xsd:string |
| http://purl.uniprot.org/citations/31907535 | http://purl.uniprot.org/core/volume | "30"xsd:string |
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