| http://purl.uniprot.org/citations/31910160 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31910160 | http://www.w3.org/2000/01/rdf-schema#comment | "Aberrant expression of the cardiac gap junction protein connexin-43 (Cx43) has been suggested as playing a role in the development of cardiac disease in the mdx mouse model of Duchenne muscular dystrophy (DMD); however, a mechanistic understanding of this association is lacking. Here, we identified a reduction of phosphorylation of Cx43 serines S325/S328/S330 in human and mouse DMD hearts. We hypothesized that hypophosphorylation of Cx43 serine-triplet triggers pathological Cx43 redistribution to the lateral sides of cardiomyocytes (remodeling). Therefore, we generated knockin mdx mice in which the Cx43 serine-triplet was replaced with either phospho-mimicking glutamic acids (mdxS3E) or nonphosphorylatable alanines (mdxS3A). The mdxS3E, but not mdxS3A, mice were resistant to Cx43 remodeling, with a corresponding reduction of Cx43 hemichannel activity. MdxS3E cardiomyocytes displayed improved intracellular Ca2+ signaling and a reduction of NADPH oxidase 2 (NOX2)/ROS production. Furthermore, mdxS3E mice were protected against inducible arrhythmias, related lethality, and the development of cardiomyopathy. Inhibition of microtubule polymerization by colchicine reduced both NOX2/ROS and oxidized CaMKII, increased S325/S328/S330 phosphorylation, and prevented Cx43 remodeling in mdx hearts. Together, these results demonstrate a mechanism of dystrophic Cx43 remodeling and suggest that targeting Cx43 may be a therapeutic strategy for preventing heart dysfunction and arrhythmias in DMD patients."xsd:string |
| http://purl.uniprot.org/citations/31910160 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci128190"xsd:string |
| http://purl.uniprot.org/citations/31910160 | http://purl.uniprot.org/core/author | "Li H."xsd:string |
| http://purl.uniprot.org/citations/31910160 | http://purl.uniprot.org/core/author | "Liu T."xsd:string |
| http://purl.uniprot.org/citations/31910160 | http://purl.uniprot.org/core/author | "Zhao Q."xsd:string |
| http://purl.uniprot.org/citations/31910160 | http://purl.uniprot.org/core/author | "Gonzalez J.P."xsd:string |
| http://purl.uniprot.org/citations/31910160 | http://purl.uniprot.org/core/author | "Xie L.H."xsd:string |
| http://purl.uniprot.org/citations/31910160 | http://purl.uniprot.org/core/author | "Contreras J.E."xsd:string |
| http://purl.uniprot.org/citations/31910160 | http://purl.uniprot.org/core/author | "Lampe P.D."xsd:string |
| http://purl.uniprot.org/citations/31910160 | http://purl.uniprot.org/core/author | "Fishman G.I."xsd:string |
| http://purl.uniprot.org/citations/31910160 | http://purl.uniprot.org/core/author | "Wehrens X.H."xsd:string |
| http://purl.uniprot.org/citations/31910160 | http://purl.uniprot.org/core/author | "Fraidenraich D."xsd:string |
| http://purl.uniprot.org/citations/31910160 | http://purl.uniprot.org/core/author | "Shirokova N."xsd:string |
| http://purl.uniprot.org/citations/31910160 | http://purl.uniprot.org/core/author | "Himelman E."xsd:string |
| http://purl.uniprot.org/citations/31910160 | http://purl.uniprot.org/core/author | "Lillo M.A."xsd:string |
| http://purl.uniprot.org/citations/31910160 | http://purl.uniprot.org/core/author | "Nouet J."xsd:string |
| http://purl.uniprot.org/citations/31910160 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/31910160 | http://purl.uniprot.org/core/name | "J Clin Invest"xsd:string |
| http://purl.uniprot.org/citations/31910160 | http://purl.uniprot.org/core/pages | "1713-1727"xsd:string |
| http://purl.uniprot.org/citations/31910160 | http://purl.uniprot.org/core/title | "Prevention of connexin-43 remodeling protects against Duchenne muscular dystrophy cardiomyopathy."xsd:string |
| http://purl.uniprot.org/citations/31910160 | http://purl.uniprot.org/core/volume | "130"xsd:string |
| http://purl.uniprot.org/citations/31910160 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31910160 |
| http://purl.uniprot.org/citations/31910160 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31910160 |
| http://purl.uniprot.org/uniprot/#_A0A023ZT56-mappedCitation-31910160 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31910160 |