| http://purl.uniprot.org/citations/31924474 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31924474 | http://www.w3.org/2000/01/rdf-schema#comment | "In addition to helper and regulatory potential, CD4+ T cells also acquire cytotoxic activity marked by granzyme B (GzmB) expression and the ability to promote rejection of established tumors. Here, we examined the molecular and cellular mechanisms underpinning the differentiation of cytotoxic CD4+ T cells following immunotherapy. CD4+ transfer into lymphodepleted animals or regulatory T (Treg) cell depletion promoted GzmB expression by tumor-infiltrating CD4+, and this was prevented by interleukin-2 (IL-2) neutralization. Transcriptional analysis revealed a polyfunctional helper and cytotoxic phenotype characterized by the expression of the transcription factors T-bet and Blimp-1. While T-bet ablation restricted interferon-γ (IFN-γ) production, loss of Blimp-1 prevented GzmB expression in response to IL-2, suggesting two independent programs required for polyfunctionality of tumor-reactive CD4+ T cells. Our findings underscore the role of Treg cells, IL-2, and Blimp-1 in controlling the differentiation of cytotoxic CD4+ T cells and offer a pathway to enhancement of anti-tumor activity through their manipulation."xsd:string |
| http://purl.uniprot.org/citations/31924474 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2019.12.007"xsd:string |
| http://purl.uniprot.org/citations/31924474 | http://purl.uniprot.org/core/author | "Ono M."xsd:string |
| http://purl.uniprot.org/citations/31924474 | http://purl.uniprot.org/core/author | "Stauss H."xsd:string |
| http://purl.uniprot.org/citations/31924474 | http://purl.uniprot.org/core/author | "Kassiotis G."xsd:string |
| http://purl.uniprot.org/citations/31924474 | http://purl.uniprot.org/core/author | "Jenner R.G."xsd:string |
| http://purl.uniprot.org/citations/31924474 | http://purl.uniprot.org/core/author | "Lord G.M."xsd:string |
| http://purl.uniprot.org/citations/31924474 | http://purl.uniprot.org/core/author | "Korn T."xsd:string |
| http://purl.uniprot.org/citations/31924474 | http://purl.uniprot.org/core/author | "Marafioti T."xsd:string |
| http://purl.uniprot.org/citations/31924474 | http://purl.uniprot.org/core/author | "Ariyan C.E."xsd:string |
| http://purl.uniprot.org/citations/31924474 | http://purl.uniprot.org/core/author | "Solomon I."xsd:string |
| http://purl.uniprot.org/citations/31924474 | http://purl.uniprot.org/core/author | "Peggs K.S."xsd:string |
| http://purl.uniprot.org/citations/31924474 | http://purl.uniprot.org/core/author | "Seddon B."xsd:string |
| http://purl.uniprot.org/citations/31924474 | http://purl.uniprot.org/core/author | "Pule M."xsd:string |
| http://purl.uniprot.org/citations/31924474 | http://purl.uniprot.org/core/author | "Quezada S.A."xsd:string |
| http://purl.uniprot.org/citations/31924474 | http://purl.uniprot.org/core/author | "Bergerhoff K."xsd:string |
| http://purl.uniprot.org/citations/31924474 | http://purl.uniprot.org/core/author | "Sledzinska A."xsd:string |
| http://purl.uniprot.org/citations/31924474 | http://purl.uniprot.org/core/author | "Vargas F.A."xsd:string |
| http://purl.uniprot.org/citations/31924474 | http://purl.uniprot.org/core/author | "Ghorani E."xsd:string |
| http://purl.uniprot.org/citations/31924474 | http://purl.uniprot.org/core/author | "Akarca A.U."xsd:string |
| http://purl.uniprot.org/citations/31924474 | http://purl.uniprot.org/core/author | "Hotblack A."xsd:string |
| http://purl.uniprot.org/citations/31924474 | http://purl.uniprot.org/core/author | "Demane D.F."xsd:string |
| http://purl.uniprot.org/citations/31924474 | http://purl.uniprot.org/core/author | "Marzolini M.A.V."xsd:string |
| http://purl.uniprot.org/citations/31924474 | http://purl.uniprot.org/core/author | "Vila de Mucha M."xsd:string |