| http://purl.uniprot.org/citations/31924648 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31924648 | http://www.w3.org/2000/01/rdf-schema#comment | "T cell development and homeostasis requires IL-7R α-chain (IL-7Rα) signaling. Tyrosine Y449 of the IL-7Rα is essential to activate STAT5 and PI3K, whereas PI3K recruitment requires IL-7Rα methionine M452. How IL-7Rα activates and regulates both signaling pathways differentially remains unclear. To characterize differential signaling, we established two lines of IL-7Rα mutant mice: IL-7R-Y449F mice and IL-7R-M452L mice. IL-7R-Y449F mice showed decreased PI3K and STAT5 signals, whereas IL-7R-M452L mice showed decreased PI3K but significantly increased STAT5 signaling, owing to a competition between PI3K and STAT5 signaling through Y449 of IL-7Rα. The number of T, B, and mature innate lymphoid cells were markedly reduced in IL-7R-Y449F mice, whereas IL-7R-M452L mice showed impaired early T cell development and memory precursor effector T cell maintenance with the downregulation of transcription factor T cell factor-1. Peripheral T cell numbers increased in IL-7R-M452L mice with enhanced survival and homeostatic proliferation. Furthermore, although wild type and IL-7R-Y449F mice showed comparable Th1/Th2 differentiation, IL-7R-M452L mice exhibited impaired Th17 differentiation. We conclude that PI3K competes with STAT5 under IL-7Rα and maintains an appropriate signal balance for modulating T cell development and homeostasis. To our knowledge, this study provides a new insight into complex regulation of IL-7Rα signaling, which supports immune development and responses."xsd:string |
| http://purl.uniprot.org/citations/31924648 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1900456"xsd:string |
| http://purl.uniprot.org/citations/31924648 | http://purl.uniprot.org/core/author | "Hara T."xsd:string |
| http://purl.uniprot.org/citations/31924648 | http://purl.uniprot.org/core/author | "Zhu Y."xsd:string |
| http://purl.uniprot.org/citations/31924648 | http://purl.uniprot.org/core/author | "Yamada H."xsd:string |
| http://purl.uniprot.org/citations/31924648 | http://purl.uniprot.org/core/author | "Matsuoka M."xsd:string |
| http://purl.uniprot.org/citations/31924648 | http://purl.uniprot.org/core/author | "Abe A."xsd:string |
| http://purl.uniprot.org/citations/31924648 | http://purl.uniprot.org/core/author | "Ma G."xsd:string |
| http://purl.uniprot.org/citations/31924648 | http://purl.uniprot.org/core/author | "Ikuta K."xsd:string |
| http://purl.uniprot.org/citations/31924648 | http://purl.uniprot.org/core/author | "Takahara K."xsd:string |
| http://purl.uniprot.org/citations/31924648 | http://purl.uniprot.org/core/author | "Asahi T."xsd:string |
| http://purl.uniprot.org/citations/31924648 | http://purl.uniprot.org/core/author | "Cui G."xsd:string |
| http://purl.uniprot.org/citations/31924648 | http://purl.uniprot.org/core/author | "Ueki K."xsd:string |
| http://purl.uniprot.org/citations/31924648 | http://purl.uniprot.org/core/author | "Kitano S."xsd:string |
| http://purl.uniprot.org/citations/31924648 | http://purl.uniprot.org/core/author | "Yoshikai Y."xsd:string |
| http://purl.uniprot.org/citations/31924648 | http://purl.uniprot.org/core/author | "Tani-Ichi S."xsd:string |
| http://purl.uniprot.org/citations/31924648 | http://purl.uniprot.org/core/author | "Miyachi H."xsd:string |
| http://purl.uniprot.org/citations/31924648 | http://purl.uniprot.org/core/author | "Suwanai H."xsd:string |
| http://purl.uniprot.org/citations/31924648 | http://purl.uniprot.org/core/author | "Shimba A."xsd:string |
| http://purl.uniprot.org/citations/31924648 | http://purl.uniprot.org/core/author | "Yasunaga J.I."xsd:string |
| http://purl.uniprot.org/citations/31924648 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/31924648 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/31924648 | http://purl.uniprot.org/core/pages | "844-857"xsd:string |
| http://purl.uniprot.org/citations/31924648 | http://purl.uniprot.org/core/title | "IL-7R-Dependent Phosphatidylinositol 3-Kinase Competes with the STAT5 Signal to Modulate T Cell Development and Homeostasis."xsd:string |