| http://purl.uniprot.org/citations/31932071 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31932071 | http://www.w3.org/2000/01/rdf-schema#comment | "Prior studies reported that haploinsufficiency of the transcription factor ETS-1 is renoprotective in Dahl salt-sensitive rats, but the mechanism is unclear. Here, we tested whether ETS-1 is involved in hypertension-induced renal microvascular pathology and autoregulatory impairment. Hypertension was induced in salt-sensitive rats and salt-sensitive rats that are heterozygous with 1 wild-type or reference allele of Ets1 (SSEts1+/-) by feeding a diet containing 4% sodium chloride for 1 week. Increases in blood pressure did not differ. However, phosphorylated ETS-1 increased in afferent arterioles of hypertensive salt-sensitive rats, but not in hypertensive SSEts1+/- rats. Afferent arterioles of hypertensive salt-sensitive rats showed increased monocyte chemotactic protein-1 expression and infiltration of CD68 positive monocytes/macrophages. Isolated kidney microvessels showed increased mRNA expression of vascular cell adhesion molecule, intercellular adhesion molecule, P-selectin, fibronectin, transforming growth factor-β, and collagen I in hypertensive salt-sensitive rats compared with hypertensive SSEts1+/- rats. Using the in vitro blood-perfused juxtamedullary nephron preparation, pressure-mediated afferent arteriolar responses were significantly blunted in hypertensive salt-sensitive rats compared to hypertensive SSEts1+/- rats. Over a 65-170 mm Hg pressure range tested baseline arteriolar diameters averaged 15.1 μm and remained between 107% and 89% of baseline diameter in hypertensive salt-sensitive rats vs. 114% and 73% in hypertensive SSEts1+/- rats (significantly different). Thus, ETS-1 participates in renal arteriolar pathology and autoregulation and thereby is involved in hypertension-mediated kidney injury in salt-sensitive rats."xsd:string |
| http://purl.uniprot.org/citations/31932071 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.kint.2019.09.025"xsd:string |
| http://purl.uniprot.org/citations/31932071 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/31932071 | http://purl.uniprot.org/core/author | "Guan Z."xsd:string |
| http://purl.uniprot.org/citations/31932071 | http://purl.uniprot.org/core/author | "Feng W."xsd:string |
| http://purl.uniprot.org/citations/31932071 | http://purl.uniprot.org/core/author | "Xing D."xsd:string |
| http://purl.uniprot.org/citations/31932071 | http://purl.uniprot.org/core/author | "Sanders P.W."xsd:string |
| http://purl.uniprot.org/citations/31932071 | http://purl.uniprot.org/core/author | "Ying W.Z."xsd:string |
| http://purl.uniprot.org/citations/31932071 | http://purl.uniprot.org/core/author | "Inscho E.W."xsd:string |
| http://purl.uniprot.org/citations/31932071 | http://purl.uniprot.org/core/author | "Remedies C.E."xsd:string |
| http://purl.uniprot.org/citations/31932071 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/31932071 | http://purl.uniprot.org/core/name | "Kidney Int"xsd:string |
| http://purl.uniprot.org/citations/31932071 | http://purl.uniprot.org/core/pages | "528-537"xsd:string |
| http://purl.uniprot.org/citations/31932071 | http://purl.uniprot.org/core/title | "Avian erythroblastosis virus E26 oncogene homolog-1 (ETS-1) plays a role in renal microvascular pathophysiology in the Dahl salt-sensitive rat."xsd:string |
| http://purl.uniprot.org/citations/31932071 | http://purl.uniprot.org/core/volume | "97"xsd:string |
| http://purl.uniprot.org/citations/31932071 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31932071 |
| http://purl.uniprot.org/citations/31932071 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31932071 |
| http://purl.uniprot.org/uniprot/P41156#attribution-CCE60184F8710B181BCBDD5A250A7506 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/31932071 |
| http://purl.uniprot.org/uniprot/#_A0A8I5ZWK1-mappedCitation-31932071 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31932071 |
| http://purl.uniprot.org/uniprot/#_A6JYI8-mappedCitation-31932071 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31932071 |
| http://purl.uniprot.org/uniprot/#_A0A8I5ZPA0-mappedCitation-31932071 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31932071 |
| http://purl.uniprot.org/uniprot/#_A0A8I6AE74-mappedCitation-31932071 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31932071 |
| http://purl.uniprot.org/uniprot/#_A0A8I6AEK6-mappedCitation-31932071 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31932071 |
| http://purl.uniprot.org/uniprot/#_P41156-mappedCitation-31932071 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31932071 |