| http://purl.uniprot.org/citations/31932628 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31932628 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31932628 | http://www.w3.org/2000/01/rdf-schema#comment | "NOD-like receptors (NLRs) localize in the cytosol to recognize intracellular pathogen products and initialize the innate immune response. However, the ligands and ligand specificity of many NLRs remain unclear. One such NLR, NLRP6, plays an important role in maintaining intestinal homeostasis and protecting against various intestinal diseases such as colitis and intestinal tumorigenesis. Here, we show that the major component of the outer membrane of gram-negative bacteria, lipopolysaccharide (LPS), binds NLRP6 directly and induces global conformational change and dimerization. Following stimulation by ATP, the NLRP6 homodimer can further assemble into a linear molecular platform, and ASC is recruited to form higher molecular structures, indicative of a step-by-step activation mechanism. Our study sheds light on the mystery of LPS-induced inflammasome initiation, reveals the architecture and structural basis of potential pre-inflammasome, and suggests a novel molecular assembly pattern for immune receptors."xsd:string |
| http://purl.uniprot.org/citations/31932628 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41598-019-57043-0"xsd:string |
| http://purl.uniprot.org/citations/31932628 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41598-019-57043-0"xsd:string |
| http://purl.uniprot.org/citations/31932628 | http://purl.uniprot.org/core/author | "Fang R."xsd:string |
| http://purl.uniprot.org/citations/31932628 | http://purl.uniprot.org/core/author | "Fang R."xsd:string |
| http://purl.uniprot.org/citations/31932628 | http://purl.uniprot.org/core/author | "Guan Y."xsd:string |
| http://purl.uniprot.org/citations/31932628 | http://purl.uniprot.org/core/author | "Guan Y."xsd:string |
| http://purl.uniprot.org/citations/31932628 | http://purl.uniprot.org/core/author | "Li G."xsd:string |
| http://purl.uniprot.org/citations/31932628 | http://purl.uniprot.org/core/author | "Li G."xsd:string |
| http://purl.uniprot.org/citations/31932628 | http://purl.uniprot.org/core/author | "Qin S."xsd:string |
| http://purl.uniprot.org/citations/31932628 | http://purl.uniprot.org/core/author | "Qin S."xsd:string |
| http://purl.uniprot.org/citations/31932628 | http://purl.uniprot.org/core/author | "Wang D.C."xsd:string |
| http://purl.uniprot.org/citations/31932628 | http://purl.uniprot.org/core/author | "Wang D.C."xsd:string |
| http://purl.uniprot.org/citations/31932628 | http://purl.uniprot.org/core/author | "Sun F."xsd:string |
| http://purl.uniprot.org/citations/31932628 | http://purl.uniprot.org/core/author | "Sun F."xsd:string |
| http://purl.uniprot.org/citations/31932628 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/31932628 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/31932628 | http://purl.uniprot.org/core/author | "Xie C."xsd:string |
| http://purl.uniprot.org/citations/31932628 | http://purl.uniprot.org/core/author | "Xie C."xsd:string |
| http://purl.uniprot.org/citations/31932628 | http://purl.uniprot.org/core/author | "Yin H."xsd:string |
| http://purl.uniprot.org/citations/31932628 | http://purl.uniprot.org/core/author | "Yin H."xsd:string |
| http://purl.uniprot.org/citations/31932628 | http://purl.uniprot.org/core/author | "Zhang K."xsd:string |
| http://purl.uniprot.org/citations/31932628 | http://purl.uniprot.org/core/author | "Zhang K."xsd:string |