| http://purl.uniprot.org/citations/31933479 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31933479 | http://www.w3.org/2000/01/rdf-schema#comment | "Metastasis is a major cause of cancer mortality. We generated an autochthonous transgenic mouse model whereby conditional expression of MYC and Twist1 enables hepatocellular carcinoma (HCC) to metastasize in >90% of mice. MYC and Twist1 cooperate and their sustained expression is required to elicit a transcriptional program associated with the activation of innate immunity, through secretion of a cytokinome that elicits recruitment and polarization of tumor associated macrophages (TAMs). Systemic treatment with Ccl2 and Il13 induced MYC-HCCs to metastasize; whereas, blockade of Ccl2 and Il13 abrogated MYC/Twist1-HCC metastasis. Further, in 33 human cancers (n = 9502) MYC and TWIST1 predict poor survival (p=4.3×10-10), CCL2/IL13 expression (p<10-109) and TAM infiltration (p<10-96). Finally, in the plasma of patients with HCC (n = 25) but not cirrhosis (n = 10), CCL2 and IL13 were increased and IL13 predicted invasive tumors. Therefore, MYC and TWIST1 generally appear to cooperate in human cancer to elicit a cytokinome that enables metastasis through crosstalk between cancer and immune microenvironment."xsd:string |
| http://purl.uniprot.org/citations/31933479 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.50731"xsd:string |
| http://purl.uniprot.org/citations/31933479 | http://purl.uniprot.org/core/author | "Kim M."xsd:string |
| http://purl.uniprot.org/citations/31933479 | http://purl.uniprot.org/core/author | "Park J."xsd:string |
| http://purl.uniprot.org/citations/31933479 | http://purl.uniprot.org/core/author | "Tong L."xsd:string |
| http://purl.uniprot.org/citations/31933479 | http://purl.uniprot.org/core/author | "Hu T."xsd:string |
| http://purl.uniprot.org/citations/31933479 | http://purl.uniprot.org/core/author | "Kannan K."xsd:string |
| http://purl.uniprot.org/citations/31933479 | http://purl.uniprot.org/core/author | "Kuruvilla S."xsd:string |
| http://purl.uniprot.org/citations/31933479 | http://purl.uniprot.org/core/author | "Krishnan M."xsd:string |
| http://purl.uniprot.org/citations/31933479 | http://purl.uniprot.org/core/author | "Tran P.T."xsd:string |
| http://purl.uniprot.org/citations/31933479 | http://purl.uniprot.org/core/author | "Gentles A.J."xsd:string |
| http://purl.uniprot.org/citations/31933479 | http://purl.uniprot.org/core/author | "Felsher D.W."xsd:string |
| http://purl.uniprot.org/citations/31933479 | http://purl.uniprot.org/core/author | "Lai I."xsd:string |
| http://purl.uniprot.org/citations/31933479 | http://purl.uniprot.org/core/author | "Baylot V."xsd:string |
| http://purl.uniprot.org/citations/31933479 | http://purl.uniprot.org/core/author | "Bellovin D.I."xsd:string |
| http://purl.uniprot.org/citations/31933479 | http://purl.uniprot.org/core/author | "Gabay M."xsd:string |
| http://purl.uniprot.org/citations/31933479 | http://purl.uniprot.org/core/author | "Barbhuiya M.A."xsd:string |
| http://purl.uniprot.org/citations/31933479 | http://purl.uniprot.org/core/author | "Dhanasekaran R."xsd:string |
| http://purl.uniprot.org/citations/31933479 | http://purl.uniprot.org/core/author | "Adeniji N."xsd:string |
| http://purl.uniprot.org/citations/31933479 | http://purl.uniprot.org/core/author | "Rajan Kd A."xsd:string |
| http://purl.uniprot.org/citations/31933479 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/31933479 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/31933479 | http://purl.uniprot.org/core/pages | "e50731"xsd:string |
| http://purl.uniprot.org/citations/31933479 | http://purl.uniprot.org/core/title | "MYC and Twist1 cooperate to drive metastasis by eliciting crosstalk between cancer and innate immunity."xsd:string |