| http://purl.uniprot.org/citations/31942037 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31942037 | http://www.w3.org/2000/01/rdf-schema#comment | "Alzheimer's disease (AD) is the most common age-related form of dementia, associated with deposition of intracellular neuronal tangles consisting primarily of hyperphosphorylated microtubule-associated protein tau (p-tau) and extracellular plaques primarily comprising amyloid-β (Aβ) peptide. The p-tau tangle unit is a posttranslational modification of normal tau protein. Aβ is a neurotoxic peptide excised from the amyloid-β precursor protein (APP) by β-site APP-cleaving enzyme 1 (BACE1) and the γ-secretase complex. MicroRNAs (miRNAs) are short, single-stranded RNAs that modulate protein expression as part of the RNA-induced silencing complex (RISC). We identified miR-298 as a repressor of APP, BACE1, and the two primary forms of Aβ (Aβ40 and Aβ42) in a primary human cell culture model. Further, we discovered a novel effect of miR-298 on posttranslational levels of two specific tau moieties. Notably, miR-298 significantly reduced levels of ~55 and 50 kDa forms of the tau protein without significant alterations of total tau or other forms. In vivo overexpression of human miR-298 resulted in nonsignificant reduction of APP, BACE1, and tau in mice. Moreover, we identified two miR-298 SNPs associated with higher cerebrospinal fluid (CSF) p-tau and lower CSF Aβ42 levels in a cohort of human AD patients. Finally, levels of miR-298 varied in postmortem human temporal lobe between AD patients and age-matched non-AD controls. Our results suggest that miR-298 may be a suitable target for AD therapy."xsd:string |
| http://purl.uniprot.org/citations/31942037 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41380-019-0610-2"xsd:string |
| http://purl.uniprot.org/citations/31942037 | http://purl.uniprot.org/core/author | "Wang R."xsd:string |
| http://purl.uniprot.org/citations/31942037 | http://purl.uniprot.org/core/author | "Rinaldi C."xsd:string |
| http://purl.uniprot.org/citations/31942037 | http://purl.uniprot.org/core/author | "Lahiri D.K."xsd:string |
| http://purl.uniprot.org/citations/31942037 | http://purl.uniprot.org/core/author | "Beck J.S."xsd:string |
| http://purl.uniprot.org/citations/31942037 | http://purl.uniprot.org/core/author | "Chopra N."xsd:string |
| http://purl.uniprot.org/citations/31942037 | http://purl.uniprot.org/core/author | "Nho K."xsd:string |
| http://purl.uniprot.org/citations/31942037 | http://purl.uniprot.org/core/author | "Saykin A.J."xsd:string |
| http://purl.uniprot.org/citations/31942037 | http://purl.uniprot.org/core/author | "Pourshafie N."xsd:string |
| http://purl.uniprot.org/citations/31942037 | http://purl.uniprot.org/core/author | "Maloney B."xsd:string |
| http://purl.uniprot.org/citations/31942037 | http://purl.uniprot.org/core/author | "Counts S.E."xsd:string |
| http://purl.uniprot.org/citations/31942037 | http://purl.uniprot.org/core/author | "Niculescu A."xsd:string |
| http://purl.uniprot.org/citations/31942037 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/31942037 | http://purl.uniprot.org/core/name | "Mol Psychiatry"xsd:string |
| http://purl.uniprot.org/citations/31942037 | http://purl.uniprot.org/core/pages | "5636-5657"xsd:string |
| http://purl.uniprot.org/citations/31942037 | http://purl.uniprot.org/core/title | "MicroRNA-298 reduces levels of human amyloid-beta precursor protein (APP), beta-site APP-converting enzyme 1 (BACE1) and specific tau protein moieties."xsd:string |
| http://purl.uniprot.org/citations/31942037 | http://purl.uniprot.org/core/volume | "26"xsd:string |
| http://purl.uniprot.org/citations/31942037 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31942037 |
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