| http://purl.uniprot.org/citations/31943697 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31943697 | http://www.w3.org/2000/01/rdf-schema#comment | "Methylation of the regulatory region of the elongation of very-long-chain fatty acids-like 2 (ELOVL2) gene, an enzyme involved in elongation of long-chain polyunsaturated fatty acids, is one of the most robust biomarkers of human age, but the critical question of whether ELOVL2 plays a functional role in molecular aging has not been resolved. Here, we report that Elovl2 regulates age-associated functional and anatomical aging in vivo, focusing on mouse retina, with direct relevance to age-related eye diseases. We show that an age-related decrease in Elovl2 expression is associated with increased DNA methylation of its promoter. Reversal of Elovl2 promoter hypermethylation in vivo through intravitreal injection of 5-Aza-2'-deoxycytidine (5-Aza-dc) leads to increased Elovl2 expression and rescue of age-related decline in visual function. Mice carrying a point mutation C234W that disrupts Elovl2-specific enzymatic activity show electrophysiological characteristics of premature visual decline, as well as early appearance of autofluorescent deposits, well-established markers of aging in the mouse retina. Finally, we find deposits underneath the retinal pigment epithelium in Elovl2 mutant mice, containing components found in human drusen, a pathologic hallmark of age related macular degeneration. These findings indicate that ELOVL2 activity regulates aging in mouse retina, provide a molecular link between polyunsaturated fatty acids elongation and visual function, and suggest novel therapeutic strategies for the treatment of age-related eye diseases."xsd:string |
| http://purl.uniprot.org/citations/31943697 | http://purl.org/dc/terms/identifier | "doi:10.1111/acel.13100"xsd:string |
| http://purl.uniprot.org/citations/31943697 | http://purl.uniprot.org/core/author | "Chen D."xsd:string |
| http://purl.uniprot.org/citations/31943697 | http://purl.uniprot.org/core/author | "Wang T."xsd:string |
| http://purl.uniprot.org/citations/31943697 | http://purl.uniprot.org/core/author | "Zhang K."xsd:string |
| http://purl.uniprot.org/citations/31943697 | http://purl.uniprot.org/core/author | "Saghatelian A."xsd:string |
| http://purl.uniprot.org/citations/31943697 | http://purl.uniprot.org/core/author | "Kolar M."xsd:string |
| http://purl.uniprot.org/citations/31943697 | http://purl.uniprot.org/core/author | "Hamilton B.A."xsd:string |
| http://purl.uniprot.org/citations/31943697 | http://purl.uniprot.org/core/author | "Ross K.D."xsd:string |
| http://purl.uniprot.org/citations/31943697 | http://purl.uniprot.org/core/author | "Skowronska-Krawczyk D."xsd:string |
| http://purl.uniprot.org/citations/31943697 | http://purl.uniprot.org/core/author | "Krawczyk M."xsd:string |
| http://purl.uniprot.org/citations/31943697 | http://purl.uniprot.org/core/author | "Chao D.L."xsd:string |
| http://purl.uniprot.org/citations/31943697 | http://purl.uniprot.org/core/author | "Jabari M."xsd:string |
| http://purl.uniprot.org/citations/31943697 | http://purl.uniprot.org/core/author | "Rocha L."xsd:string |
| http://purl.uniprot.org/citations/31943697 | http://purl.uniprot.org/core/author | "Jafari M."xsd:string |
| http://purl.uniprot.org/citations/31943697 | http://purl.uniprot.org/core/author | "Nguyen Huu V.A."xsd:string |
| http://purl.uniprot.org/citations/31943697 | http://purl.uniprot.org/core/author | "Dasyani M."xsd:string |
| http://purl.uniprot.org/citations/31943697 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/31943697 | http://purl.uniprot.org/core/name | "Aging Cell"xsd:string |
| http://purl.uniprot.org/citations/31943697 | http://purl.uniprot.org/core/pages | "e13100"xsd:string |
| http://purl.uniprot.org/citations/31943697 | http://purl.uniprot.org/core/title | "The lipid elongation enzyme ELOVL2 is a molecular regulator of aging in the retina."xsd:string |
| http://purl.uniprot.org/citations/31943697 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/31943697 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31943697 |
| http://purl.uniprot.org/citations/31943697 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31943697 |