| http://purl.uniprot.org/citations/31948942 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31948942 | http://www.w3.org/2000/01/rdf-schema#comment | "Mutations in Sonic hedgehog (SHH) signaling promote aberrant proliferation and tumor growth. SHH-medulloblastoma (MB) is among the most frequent brain tumors in children less than 3 years of age. Although key components of the SHH pathway are well-known, we hypothesized that new disease-modifying targets of SHH-MB might be identified from large-scale bioinformatics and systems biology analyses. Using a data-driven systems biology approach, we built a MB-specific interactome. The ATP-binding cassette transporter ABCC4 was identified as a modulator of SHH-MB. Accordingly, increased ABCC4 expression correlated with poor overall survival in patients with SHH-MB. Knockdown of ABCC4 expression markedly blunted the constitutive activation of the SHH pathway secondary to Ptch1 or Sufu insufficiency. In human tumor cell lines, ABCC4 knockdown and inhibition reduced full-length GLI3 levels. In a clinically relevant murine SHH-MB model, targeted ablation of Abcc4 in primary tumors significantly reduced tumor burden and extended the lifespan of tumor-bearing mice. These studies reveal ABCC4 as a potent SHH pathway regulator and a new candidate to target with the potential to improve SHH-MB therapy. SIGNIFICANCE: These findings identify ABCC4 transporter as a new target in SHH-MB, prompting the development of inhibitors or the repurporsing of existing drugs to target ABCC4."xsd:string |
| http://purl.uniprot.org/citations/31948942 | http://purl.org/dc/terms/identifier | "doi:10.1158/0008-5472.can-19-2054"xsd:string |
| http://purl.uniprot.org/citations/31948942 | http://purl.uniprot.org/core/author | "Liu J."xsd:string |
| http://purl.uniprot.org/citations/31948942 | http://purl.uniprot.org/core/author | "Peng J."xsd:string |
| http://purl.uniprot.org/citations/31948942 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/31948942 | http://purl.uniprot.org/core/author | "Wu G."xsd:string |
| http://purl.uniprot.org/citations/31948942 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/31948942 | http://purl.uniprot.org/core/author | "Xu B."xsd:string |
| http://purl.uniprot.org/citations/31948942 | http://purl.uniprot.org/core/author | "Yu J."xsd:string |
| http://purl.uniprot.org/citations/31948942 | http://purl.uniprot.org/core/author | "Schuetz J.D."xsd:string |
| http://purl.uniprot.org/citations/31948942 | http://purl.uniprot.org/core/author | "Roussel M.F."xsd:string |
| http://purl.uniprot.org/citations/31948942 | http://purl.uniprot.org/core/author | "Janke L.J."xsd:string |
| http://purl.uniprot.org/citations/31948942 | http://purl.uniprot.org/core/author | "Orr B.A."xsd:string |
| http://purl.uniprot.org/citations/31948942 | http://purl.uniprot.org/core/author | "Vo B.T."xsd:string |
| http://purl.uniprot.org/citations/31948942 | http://purl.uniprot.org/core/author | "Wijaya J."xsd:string |
| http://purl.uniprot.org/citations/31948942 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/31948942 | http://purl.uniprot.org/core/name | "Cancer Res"xsd:string |
| http://purl.uniprot.org/citations/31948942 | http://purl.uniprot.org/core/pages | "1524-1537"xsd:string |
| http://purl.uniprot.org/citations/31948942 | http://purl.uniprot.org/core/title | "An ABC Transporter Drives Medulloblastoma Pathogenesis by Regulating Sonic Hedgehog Signaling."xsd:string |
| http://purl.uniprot.org/citations/31948942 | http://purl.uniprot.org/core/volume | "80"xsd:string |
| http://purl.uniprot.org/citations/31948942 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31948942 |
| http://purl.uniprot.org/citations/31948942 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31948942 |
| http://purl.uniprot.org/uniprot/#_A8K2Q2-mappedCitation-31948942 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31948942 |
| http://purl.uniprot.org/uniprot/#_A0A5C0NTB8-mappedCitation-31948942 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31948942 |