| http://purl.uniprot.org/citations/31960388 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31960388 | http://www.w3.org/2000/01/rdf-schema#comment | "Arsenic is a well-known human carcinogen. However, the mechanisms underlying arsenic-induced carcinogenesis remain elusive. Here we show that chronic and low level of arsenic stress induces transformation of the human bronchial epithelial cells, BEAS-2B, and that some of the transformed cells show characteristics of cancer stem-like cells (CSCs). Meanwhile, we demonstrate that arsenic stress dedifferentiates CD61+ BEAS-2B cells into CSC-like CD61- cells featured with noncanonical epithelial-mesenchymal transition (EMT), enhanced chemoresistance, and metastasis. Finally, we show that oncogene c-Myc expression is associated with arsenic-induced tumor initiation and progression. Altogether, our findings highlight a unique mechanism of arsenic-induced transformation of human bronchial epithelial cells and provide a novel therapeutic target for arsenic-initiated lung cancer."xsd:string |
| http://purl.uniprot.org/citations/31960388 | http://purl.org/dc/terms/identifier | "doi:10.1007/978-1-0716-0301-7_19"xsd:string |
| http://purl.uniprot.org/citations/31960388 | http://purl.uniprot.org/core/author | "Chen F."xsd:string |
| http://purl.uniprot.org/citations/31960388 | http://purl.uniprot.org/core/author | "Fu Y."xsd:string |
| http://purl.uniprot.org/citations/31960388 | http://purl.uniprot.org/core/author | "Lu Y."xsd:string |
| http://purl.uniprot.org/citations/31960388 | http://purl.uniprot.org/core/author | "Zhang Q."xsd:string |
| http://purl.uniprot.org/citations/31960388 | http://purl.uniprot.org/core/author | "Xu L."xsd:string |
| http://purl.uniprot.org/citations/31960388 | http://purl.uniprot.org/core/author | "Zhang W."xsd:string |
| http://purl.uniprot.org/citations/31960388 | http://purl.uniprot.org/core/author | "Chang Q."xsd:string |
| http://purl.uniprot.org/citations/31960388 | http://purl.uniprot.org/core/author | "Bi Z."xsd:string |
| http://purl.uniprot.org/citations/31960388 | http://purl.uniprot.org/core/author | "Almutairy B."xsd:string |
| http://purl.uniprot.org/citations/31960388 | http://purl.uniprot.org/core/author | "Wadgaonkar P."xsd:string |
| http://purl.uniprot.org/citations/31960388 | http://purl.uniprot.org/core/author | "Rice M.K.A."xsd:string |
| http://purl.uniprot.org/citations/31960388 | http://purl.uniprot.org/core/author | "Thukar C."xsd:string |
| http://purl.uniprot.org/citations/31960388 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/31960388 | http://purl.uniprot.org/core/name | "Methods Mol Biol"xsd:string |
| http://purl.uniprot.org/citations/31960388 | http://purl.uniprot.org/core/pages | "293-303"xsd:string |
| http://purl.uniprot.org/citations/31960388 | http://purl.uniprot.org/core/title | "Characterization of Arsenic-Induced Cancer Stem-Like Cells."xsd:string |
| http://purl.uniprot.org/citations/31960388 | http://purl.uniprot.org/core/volume | "2117"xsd:string |
| http://purl.uniprot.org/citations/31960388 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31960388 |
| http://purl.uniprot.org/citations/31960388 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31960388 |
| http://purl.uniprot.org/uniprot/#_A0A0B4J1R1-mappedCitation-31960388 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31960388 |
| http://purl.uniprot.org/uniprot/#_A0N2G3-mappedCitation-31960388 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31960388 |
| http://purl.uniprot.org/uniprot/#_A0A224B085-mappedCitation-31960388 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31960388 |