| http://purl.uniprot.org/citations/31960591 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31960591 | http://www.w3.org/2000/01/rdf-schema#comment | "Blockade of cell cycle re-entry in quiescent cancer cells is a strategy to prevent cancer progression and recurrence. We investigated the action and mode of action of CPF mixture (Coptis chinensis, Pinellia ternata and Fructus trichosanthis) in impeding a proliferative switch in quiescent lung cancer cells. The results indicated that CPF impeded cell cycle re-entry in quiescent lung cancer cells by reduction of FACT and c-MYC mRNA and protein levels, with concomitant decrease in H3K4 tri-methylation and RNA polymerase II occupancy at FACT and c-MYC promoter regions. Animals implanted with quiescent cancer cells that had been exposed to CPF had reduced tumour volume/weight. Thus, CPF suppresses proliferative switching through transcriptional suppression of FACT and the c-MYC, providing a new insight into therapeutic target and intervention method in impeding cancer recurrence."xsd:string |
| http://purl.uniprot.org/citations/31960591 | http://purl.org/dc/terms/identifier | "doi:10.1111/jcmm.14897"xsd:string |
| http://purl.uniprot.org/citations/31960591 | http://purl.uniprot.org/core/author | "Jin S."xsd:string |
| http://purl.uniprot.org/citations/31960591 | http://purl.uniprot.org/core/author | "Liu T."xsd:string |
| http://purl.uniprot.org/citations/31960591 | http://purl.uniprot.org/core/author | "Kang Y."xsd:string |
| http://purl.uniprot.org/citations/31960591 | http://purl.uniprot.org/core/author | "Shi X."xsd:string |
| http://purl.uniprot.org/citations/31960591 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/31960591 | http://purl.uniprot.org/core/author | "Zhou J."xsd:string |
| http://purl.uniprot.org/citations/31960591 | http://purl.uniprot.org/core/author | "Xu L."xsd:string |
| http://purl.uniprot.org/citations/31960591 | http://purl.uniprot.org/core/author | "Wang Q."xsd:string |
| http://purl.uniprot.org/citations/31960591 | http://purl.uniprot.org/core/author | "Zhao X."xsd:string |
| http://purl.uniprot.org/citations/31960591 | http://purl.uniprot.org/core/author | "Xie C."xsd:string |
| http://purl.uniprot.org/citations/31960591 | http://purl.uniprot.org/core/author | "Wang Y.'"xsd:string |
| http://purl.uniprot.org/citations/31960591 | http://purl.uniprot.org/core/author | "Dong Q."xsd:string |
| http://purl.uniprot.org/citations/31960591 | http://purl.uniprot.org/core/author | "Mu Y."xsd:string |
| http://purl.uniprot.org/citations/31960591 | http://purl.uniprot.org/core/author | "Ge G."xsd:string |
| http://purl.uniprot.org/citations/31960591 | http://purl.uniprot.org/core/author | "Jiao L."xsd:string |
| http://purl.uniprot.org/citations/31960591 | http://purl.uniprot.org/core/author | "Bi L."xsd:string |
| http://purl.uniprot.org/citations/31960591 | http://purl.uniprot.org/core/author | "De Souza P."xsd:string |
| http://purl.uniprot.org/citations/31960591 | http://purl.uniprot.org/core/author | "Hnit S.S.T."xsd:string |
| http://purl.uniprot.org/citations/31960591 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/31960591 | http://purl.uniprot.org/core/name | "J Cell Mol Med"xsd:string |
| http://purl.uniprot.org/citations/31960591 | http://purl.uniprot.org/core/pages | "2229-2239"xsd:string |
| http://purl.uniprot.org/citations/31960591 | http://purl.uniprot.org/core/title | "CPF impedes cell cycle re-entry of quiescent lung cancer cells through transcriptional suppression of FACT and c-MYC."xsd:string |