| http://purl.uniprot.org/citations/31961823 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31961823 | http://www.w3.org/2000/01/rdf-schema#comment | "Extracellular matrix and osmolarity influence the development and homeostasis of skeletal tissues through Rho GTPase-mediated alteration of the actin cytoskeleton. This study investigated whether the actin-branching Arp2/3 complex, a downstream effector of the Rho GTPases Cdc42 and Rac1, plays a critical role in maintaining the health of matrix-rich and osmotically loaded intervertebral discs and cartilage. Mice with constitutive intervertebral disc- and cartilage-specific deletion of the critical Arp2/3 subunit Arpc2 (Col2-Cre; Arpc2fl/fl) developed chondrodysplasia and spinal defects. Since these mice did not survive to adulthood, we generated mice with inducible Arpc2 deletion in disc and cartilage (Acan-CreERT2; Arpc2fl/fl). Inactivation of Arp2/3 at skeletal maturity resulted in growth plate closure, loss of proteoglycan content in articular cartilage, and degenerative changes in the intervertebral disc at 1 year of age. Chondrocytes with Arpc2 deletion showed compromised cell spreading on both collagen and fibronectin. Pharmacological inhibition of Cdc42 and Arp2/3 prevented the osmoadaptive transcription factor TonEBP/NFAT5 from recruiting cofactors in response to a hyperosmolarity challenge. Together, these findings suggest that Arp2/3 plays a critical role in cartilaginous tissues through the regulation of cell-extracellular matrix interactions and modulation of TonEBP-mediated osmoadaptation."xsd:string |
| http://purl.uniprot.org/citations/31961823 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci.insight.131382"xsd:string |
| http://purl.uniprot.org/citations/31961823 | http://purl.uniprot.org/core/author | "Bear J.E."xsd:string |
| http://purl.uniprot.org/citations/31961823 | http://purl.uniprot.org/core/author | "Tessier S."xsd:string |
| http://purl.uniprot.org/citations/31961823 | http://purl.uniprot.org/core/author | "Rotty J.D."xsd:string |
| http://purl.uniprot.org/citations/31961823 | http://purl.uniprot.org/core/author | "Shapiro I.M."xsd:string |
| http://purl.uniprot.org/citations/31961823 | http://purl.uniprot.org/core/author | "Sao K."xsd:string |
| http://purl.uniprot.org/citations/31961823 | http://purl.uniprot.org/core/author | "Loeser R.F."xsd:string |
| http://purl.uniprot.org/citations/31961823 | http://purl.uniprot.org/core/author | "Ulici V."xsd:string |
| http://purl.uniprot.org/citations/31961823 | http://purl.uniprot.org/core/author | "Risbud M.V."xsd:string |
| http://purl.uniprot.org/citations/31961823 | http://purl.uniprot.org/core/author | "Diekman B.O."xsd:string |
| http://purl.uniprot.org/citations/31961823 | http://purl.uniprot.org/core/author | "Doolittle A.C."xsd:string |
| http://purl.uniprot.org/citations/31961823 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/31961823 | http://purl.uniprot.org/core/name | "JCI Insight"xsd:string |
| http://purl.uniprot.org/citations/31961823 | http://purl.uniprot.org/core/pages | "131382"xsd:string |
| http://purl.uniprot.org/citations/31961823 | http://purl.uniprot.org/core/title | "Arp2/3 inactivation causes intervertebral disc and cartilage degeneration with dysregulated TonEBP-mediated osmoadaptation."xsd:string |
| http://purl.uniprot.org/citations/31961823 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/31961823 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31961823 |
| http://purl.uniprot.org/citations/31961823 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31961823 |
| http://purl.uniprot.org/uniprot/#_A0A087WPR6-mappedCitation-31961823 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31961823 |
| http://purl.uniprot.org/uniprot/#_A0A087WQ14-mappedCitation-31961823 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31961823 |
| http://purl.uniprot.org/uniprot/#_A0A087WQ83-mappedCitation-31961823 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31961823 |
| http://purl.uniprot.org/uniprot/#_A0A087WP86-mappedCitation-31961823 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31961823 |
| http://purl.uniprot.org/uniprot/#_A0A087WS98-mappedCitation-31961823 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31961823 |