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http://purl.uniprot.org/citations/31962332http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/31962332http://www.w3.org/2000/01/rdf-schema#comment"

Objective

In obese individuals, chronic low-grade inflammation resulting from adipocyte-macrophage interactions is a major cause of adipose tissue dysfunction and metabolic disease. This study investigated the role of MAP kinase phosphatase-5 (MKP-5) in obesity-induced inflammation during macrophage and adipocyte interactions.

Methods

High-fat diet-induced obese mice were used to explore the role of MKP-5 in obesity-induced adipose tissue inflammation. Macrophage polarization was determined by inflammatory cytokine expression in MKP-5-overexpressed or -silenced Raw264.7 cells exposed to palmitate (PA) or M1/M2 macrophage inducers. To uncover the role of MKP-5 during macrophage-adipocyte interactions, a coculture system composed of differentiated 3T3-L1 and Raw264.7 cells was employed. MAPK inhibitors were used to investigate the involvement of MAPK signaling.

Results

Increased MKP-5 expression was observed in adipose stromal vascular cells (SVCs) of obese mice. In Raw264.7 cells, MKP-5 promoted the switching of M1 macrophages to an M2 phenotype. Notably, MKP-5 reduced inflammation during the interaction of macrophages and adipocytes. MKP-5 overexpression in primary SVCs attenuated the expression of inflammatory mediators and increased the number of obesity-induced adipose tissue macrophages. MKP-5 suppressed PA-induced inflammation through the inactivation of P38, JNK, and ERK MAPKs.

Conclusions

MKP-5 promotes macrophages to switch from the M1 to the M2 phenotype and is an inflammatory inhibitor involved in obesity-induced adipose tissue inflammation and PA-triggered macrophage inflammation via the P38, JNK, and ERK MAPK pathways. MKP-5 may be developed into a potential therapeutic target for obesity-related diseases, including type 2 diabetes mellitus and insulin resistance."xsd:string
http://purl.uniprot.org/citations/31962332http://purl.org/dc/terms/identifier"doi:10.1159/000505343"xsd:string
http://purl.uniprot.org/citations/31962332http://purl.uniprot.org/core/author"Liu X."xsd:string
http://purl.uniprot.org/citations/31962332http://purl.uniprot.org/core/author"Lu Y."xsd:string
http://purl.uniprot.org/citations/31962332http://purl.uniprot.org/core/author"Ma J."xsd:string
http://purl.uniprot.org/citations/31962332http://purl.uniprot.org/core/author"Song Z."xsd:string
http://purl.uniprot.org/citations/31962332http://purl.uniprot.org/core/author"Zhang Q."xsd:string
http://purl.uniprot.org/citations/31962332http://purl.uniprot.org/core/author"Yan W."xsd:string
http://purl.uniprot.org/citations/31962332http://purl.uniprot.org/core/author"Zhou C."xsd:string
http://purl.uniprot.org/citations/31962332http://purl.uniprot.org/core/author"Wang W."xsd:string
http://purl.uniprot.org/citations/31962332http://purl.uniprot.org/core/author"Zhao J."xsd:string
http://purl.uniprot.org/citations/31962332http://purl.uniprot.org/core/author"Jiao P."xsd:string
http://purl.uniprot.org/citations/31962332http://purl.uniprot.org/core/author"Teng W."xsd:string
http://purl.uniprot.org/citations/31962332http://purl.uniprot.org/core/date"2020"xsd:gYear
http://purl.uniprot.org/citations/31962332http://purl.uniprot.org/core/name"Obes Facts"xsd:string
http://purl.uniprot.org/citations/31962332http://purl.uniprot.org/core/pages"86-101"xsd:string
http://purl.uniprot.org/citations/31962332http://purl.uniprot.org/core/title"The Role of MKP-5 in Adipocyte-Macrophage Interactions during Obesity."xsd:string
http://purl.uniprot.org/citations/31962332http://purl.uniprot.org/core/volume"13"xsd:string
http://purl.uniprot.org/citations/31962332http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/31962332
http://purl.uniprot.org/citations/31962332http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/31962332
http://purl.uniprot.org/uniprot/#_Q9ESS0-mappedCitation-31962332http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/31962332
http://purl.uniprot.org/uniprot/#_Q9CSL5-mappedCitation-31962332http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/31962332
http://purl.uniprot.org/uniprot/Q9CSL5http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/31962332
http://purl.uniprot.org/uniprot/Q9ESS0http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/31962332
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