| http://purl.uniprot.org/citations/31967646 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31967646 | http://www.w3.org/2000/01/rdf-schema#comment | "Dendritic cells (DCs) are critical for the differentiation of pathogen-specific CD4 T cells. However, to what extent innate cues from DCs dictate transcriptional changes in T cells remains elusive. Here, we used DCs stimulated with specific pathogens to prime CD4 T cells in vitro and found that these T cells express unique transcriptional profiles dictated by the nature of the priming pathogen. More specifically, the transcriptome of in vitro C. rodentium-primed Th17 cells resembled that of Th17 cells primed following infection in vivo but was remarkably distinct from cytokine-polarized Th17 cells. We identified caspase-1 as a unique gene up-regulated only in pathogen-primed Th17 cells and discovered a critical role for T cell-intrinsic caspase-1, independent of inflammasome, in optimal priming of Th17 responses. T cells lacking caspase-1 failed to induce colitis or confer protection against C. rodentium infection due to suboptimal Th17 cell differentiation in vivo. This study underlines the importance of DC-mediated priming in identifying novel regulators of T cell differentiation."xsd:string |
| http://purl.uniprot.org/citations/31967646 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20190476"xsd:string |
| http://purl.uniprot.org/citations/31967646 | http://purl.uniprot.org/core/author | "Gao Y."xsd:string |
| http://purl.uniprot.org/citations/31967646 | http://purl.uniprot.org/core/author | "Jain A."xsd:string |
| http://purl.uniprot.org/citations/31967646 | http://purl.uniprot.org/core/author | "Wakeland E.K."xsd:string |
| http://purl.uniprot.org/citations/31967646 | http://purl.uniprot.org/core/author | "Pasare C."xsd:string |
| http://purl.uniprot.org/citations/31967646 | http://purl.uniprot.org/core/author | "Rauch I."xsd:string |
| http://purl.uniprot.org/citations/31967646 | http://purl.uniprot.org/core/author | "Dozmorov I."xsd:string |
| http://purl.uniprot.org/citations/31967646 | http://purl.uniprot.org/core/author | "Evers B.M."xsd:string |
| http://purl.uniprot.org/citations/31967646 | http://purl.uniprot.org/core/author | "Coughlin L.A."xsd:string |
| http://purl.uniprot.org/citations/31967646 | http://purl.uniprot.org/core/author | "Koh A.Y."xsd:string |
| http://purl.uniprot.org/citations/31967646 | http://purl.uniprot.org/core/author | "Irizarry-Caro R.A."xsd:string |
| http://purl.uniprot.org/citations/31967646 | http://purl.uniprot.org/core/author | "Deason K."xsd:string |
| http://purl.uniprot.org/citations/31967646 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/31967646 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/31967646 | http://purl.uniprot.org/core/pages | "e20190476"xsd:string |
| http://purl.uniprot.org/citations/31967646 | http://purl.uniprot.org/core/title | "Transcriptional profiling identifies caspase-1 as a T cell-intrinsic regulator of Th17 differentiation."xsd:string |
| http://purl.uniprot.org/citations/31967646 | http://purl.uniprot.org/core/volume | "217"xsd:string |
| http://purl.uniprot.org/citations/31967646 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31967646 |
| http://purl.uniprot.org/citations/31967646 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31967646 |
| http://purl.uniprot.org/uniprot/#_A0A7R8C347-mappedCitation-31967646 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31967646 |
| http://purl.uniprot.org/uniprot/#_A0A571BDI1-mappedCitation-31967646 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31967646 |
| http://purl.uniprot.org/uniprot/#_A0A571BF22-mappedCitation-31967646 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31967646 |
| http://purl.uniprot.org/uniprot/#_A0A0U1RQ20-mappedCitation-31967646 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31967646 |