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http://purl.uniprot.org/citations/31980934http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/31980934http://www.w3.org/2000/01/rdf-schema#comment"

Aims

The cytoskeletal signaling protein four and-a-half LIM domains 1 (FHL-1) has recently been identified as a novel key player in pulmonary hypertension as well as in left heart diseases. In this regard, FHL-1 has been implicated in dysregulated hypertrophic signaling in pulmonary arterial smooth muscle cells leading to pulmonary hypertension. In mice, FHL-1-deficiency (FHL-1-/-) led to an attenuated hypertrophic signaling associated with a blunted hypertrophic response of the pressure-overloaded left ventricle (LV). However, the role of FHL-1 in right heart hypertrophy has not yet been addressed.

Methods and results

We investigated FHL-1 expression in C57Bl/6 mice subjected to chronic biomechanical stress and found it to be enhanced in the right ventricle (RV). Next, we subjected FHL-1-/- and corresponding wild-type mice to pressure overload of the RV by pulmonary arterial banding for various time points. However, in contrast to the previously published study in LV-pressure overload, which was confirmed here, RV hypertrophy and hypertrophic signaling was not diminished in FHL-1-/- mice. In detail, right ventricular pressure overload led to hypertrophy, dilatation and fibrosis of the RV from both FHL-1-/- and wild-type mice. RV remodeling was associated with impaired RV function as evidenced by reduced tricuspid annular plane systolic excursion. Additionally, PAB induced upregulation of natriuretic peptides and slight downregulation of phospholamban and ryanodine receptor 2 in the RV. However, there was no difference between genotypes in the degree of expression change.

Conclusion

FHL-1 pathway is not involved in the control of adverse remodeling in the pressure overloaded RV."xsd:string
http://purl.uniprot.org/citations/31980934http://purl.org/dc/terms/identifier"doi:10.1007/s00395-019-0767-5"xsd:string
http://purl.uniprot.org/citations/31980934http://purl.uniprot.org/core/author"Grimminger F."xsd:string
http://purl.uniprot.org/citations/31980934http://purl.uniprot.org/core/author"Weissmann N."xsd:string
http://purl.uniprot.org/citations/31980934http://purl.uniprot.org/core/author"Wilhelm J."xsd:string
http://purl.uniprot.org/citations/31980934http://purl.uniprot.org/core/author"Fink L."xsd:string
http://purl.uniprot.org/citations/31980934http://purl.uniprot.org/core/author"Schermuly R.T."xsd:string
http://purl.uniprot.org/citations/31980934http://purl.uniprot.org/core/author"Ghofrani H.A."xsd:string
http://purl.uniprot.org/citations/31980934http://purl.uniprot.org/core/author"Kwapiszewska G."xsd:string
http://purl.uniprot.org/citations/31980934http://purl.uniprot.org/core/author"Dahal B.K."xsd:string
http://purl.uniprot.org/citations/31980934http://purl.uniprot.org/core/author"Egemnazarov B."xsd:string
http://purl.uniprot.org/citations/31980934http://purl.uniprot.org/core/author"Sydykov A."xsd:string
http://purl.uniprot.org/citations/31980934http://purl.uniprot.org/core/author"Veith C."xsd:string
http://purl.uniprot.org/citations/31980934http://purl.uniprot.org/core/author"Fischer J.H."xsd:string
http://purl.uniprot.org/citations/31980934http://purl.uniprot.org/core/author"Luitel H."xsd:string
http://purl.uniprot.org/citations/31980934http://purl.uniprot.org/core/author"Muntanjohl C."xsd:string
http://purl.uniprot.org/citations/31980934http://purl.uniprot.org/core/author"Neghabian D."xsd:string
http://purl.uniprot.org/citations/31980934http://purl.uniprot.org/core/date"2020"xsd:gYear
http://purl.uniprot.org/citations/31980934http://purl.uniprot.org/core/name"Basic Res Cardiol"xsd:string
http://purl.uniprot.org/citations/31980934http://purl.uniprot.org/core/pages"17"xsd:string
http://purl.uniprot.org/citations/31980934http://purl.uniprot.org/core/title"FHL-1 is not involved in pressure overload-induced maladaptive right ventricular remodeling and dysfunction."xsd:string
http://purl.uniprot.org/citations/31980934http://purl.uniprot.org/core/volume"115"xsd:string
http://purl.uniprot.org/citations/31980934http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/31980934
http://purl.uniprot.org/citations/31980934http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/31980934
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