| http://purl.uniprot.org/citations/31981925 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31981925 | http://www.w3.org/2000/01/rdf-schema#comment | "Neurotransmission defects and motoneuron degeneration are hallmarks of spinal muscular atrophy, a monogenetic disease caused by the deficiency of the SMN protein. In the present study, we show that systemic application of R-Roscovitine, a Cav2.1/Cav2.2 channel modifier and a cyclin-dependent kinase 5 (Cdk-5) inhibitor, significantly improved survival of SMA mice. In addition, R-Roscovitine increased Cav2.1 channel density and sizes of the motor endplates. In vitro, R-Roscovitine restored axon lengths and growth cone sizes of Smn-deficient motoneurons corresponding to enhanced spontaneous Ca2+ influx and elevated Cav2.2 channel cluster formations independent of its capability to inhibit Cdk-5. Acute application of R-Roscovitine at the neuromuscular junction significantly increased evoked neurotransmitter release, increased the frequency of spontaneous miniature potentials, and lowered the activation threshold of silent terminals. These data indicate that R-Roscovitine improves Ca2+ signaling and Ca2+ homeostasis in Smn-deficient motoneurons, which is generally crucial for motoneuron differentiation, maturation, and function."xsd:string |
| http://purl.uniprot.org/citations/31981925 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.isci.2020.100826"xsd:string |
| http://purl.uniprot.org/citations/31981925 | http://purl.uniprot.org/core/author | "Tejero R."xsd:string |
| http://purl.uniprot.org/citations/31981925 | http://purl.uniprot.org/core/author | "Jablonka S."xsd:string |
| http://purl.uniprot.org/citations/31981925 | http://purl.uniprot.org/core/author | "Clausen J.D."xsd:string |
| http://purl.uniprot.org/citations/31981925 | http://purl.uniprot.org/core/author | "Torres-Benito L."xsd:string |
| http://purl.uniprot.org/citations/31981925 | http://purl.uniprot.org/core/author | "Blum R."xsd:string |
| http://purl.uniprot.org/citations/31981925 | http://purl.uniprot.org/core/author | "Ojeda J."xsd:string |
| http://purl.uniprot.org/citations/31981925 | http://purl.uniprot.org/core/author | "Appenzeller S."xsd:string |
| http://purl.uniprot.org/citations/31981925 | http://purl.uniprot.org/core/author | "Dombert B."xsd:string |
| http://purl.uniprot.org/citations/31981925 | http://purl.uniprot.org/core/author | "Briese M."xsd:string |
| http://purl.uniprot.org/citations/31981925 | http://purl.uniprot.org/core/author | "Balk S."xsd:string |
| http://purl.uniprot.org/citations/31981925 | http://purl.uniprot.org/core/author | "Tabares L."xsd:string |
| http://purl.uniprot.org/citations/31981925 | http://purl.uniprot.org/core/author | "Saal-Bauernschubert L."xsd:string |
| http://purl.uniprot.org/citations/31981925 | http://purl.uniprot.org/core/author | "Drexl H."xsd:string |
| http://purl.uniprot.org/citations/31981925 | http://purl.uniprot.org/core/author | "Franco-Espin J."xsd:string |
| http://purl.uniprot.org/citations/31981925 | http://purl.uniprot.org/core/author | "Hennlein L."xsd:string |
| http://purl.uniprot.org/citations/31981925 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/31981925 | http://purl.uniprot.org/core/name | "iScience"xsd:string |
| http://purl.uniprot.org/citations/31981925 | http://purl.uniprot.org/core/pages | "100826"xsd:string |
| http://purl.uniprot.org/citations/31981925 | http://purl.uniprot.org/core/title | "R-Roscovitine Improves Motoneuron Function in Mouse Models for Spinal Muscular Atrophy."xsd:string |
| http://purl.uniprot.org/citations/31981925 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/31981925 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31981925 |
| http://purl.uniprot.org/citations/31981925 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31981925 |